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[学术文献 ] Natural allelic variation in SW14 determines seed weight and quality in soybean 进入全文
Nature Communications
Seed weight and oil/protein content are critical agronomic traits that determine soybean yield and quality. However, the key genes controlling these traits and the underlying regulatory mechanisms remain poorly understood. Here, we performed a combination of genome-wide association study and quantitative trait loci (QTL) mapping with seed weight variations, and identified a Nuclear Factor-YA (NF-YA) gene on chromosome 14 that positively regulates seed weight and protein content while negatively regulating oil content without affecting other agronomic traits, designated as Seed Weight 14 (SW14). SW14 physically interacts with GmLEC1a/b, the soybean orthologs of the central regulator of plant seed development, Leafy Cotyledon1 (LEC1), to disrupt the formation of a non-canonical NF-Y complex comprising GmLEC1, GmNF-YC2, and GmbZIP67, thereby inhibiting the GmLEC1-mediated transcriptional activation involved in seed development process. Natural allelic variations in SW14 affect the stability of the SW14 protein, which in turn confers varied seed weight and oil/protein content in soybean. Further analysis demonstrates that the elite SW14H3 allele has undergone artificial selection during domestication and holds potential for improving yield in soybean. Collectively, our findings provide insights into the molecular basis that specifically regulates seed weight and quality, offering a potential strategy for overcoming tradeoff effects and facilitating high-yield breeding in soybean.
[学术文献 ] Escherichia coli with a 57-codon genetic code 进入全文
Science
The near-universal genetic code uses 64 codons to encode the 20 canonical amino acids and protein synthesis. Here we designed and generated Escherichia coli with a 4 Mb synthetic genome in which we replaced known occurrences of six sense codons and a stop codon with synonymous codons. The resulting organism, Syn57, uses 55 codons to encode the 20 canonical amino acids.
[前沿资讯 ] AI Action Plan a Critical Step for AIxBio Innovation, National Security, and Global Economic Competitiveness 进入全文
NSCEB
The National Security Commission on Emerging Biotechnology applauds the inclusion of AIxBio in the White House’s new AI Action Plan. The Action Plan includes directives designed to retain and regain U.S. leadership at the convergence of AI and biotechnology, including several actions the NSCEB recommended earlier this year. The NSCEB made four recommendations on AIxBio which are reflected in the AI Action Plan: Invest in AI-Enabled Science ；Build World-Class Scientific Datasets: AI-Ready Data ；Build World-Class Scientific Datasets: Genome Sequencing ；Invest in Biosecurity.
[科研项目 ] Netherlands: European boost for global food security: Dutch biotech Solynta gets €20 million EIB backing for highly disease resistant potato varieties 进入全文
EuropeanInvestment Bank
EIB lends €20 million to Dutch biotechnology company Solynta to develop potato seeds with strong resistance to disease and resilience to climate change. The focus of the EIB loan, which is supported under the European Commission’s InvestEU programme, is on the use of true potato seeds instead of traditional tubers for cultivation. Solynta’s technology holds promise of securing successful potato harvests and enhancing
[前沿资讯 ] Mastering siRNA Design: The Art and Science of Precision Gene Silencing 进入全文
GenScript公司
In the dynamic landscape of personalized genetic medicine, small interfering RNA (siRNA) has emerged as a transformative tool, enabling researchers to silence disease-causing genes with unprecedented precision. siRNAs are powerful molecular tools that harness the cell's natural RNA interference (RNAi) pathway to silence specific genes. These short (i.e., ~20 to 24 nucleotides) double-stranded RNA molecules guide the cellular machinery to precisely degrade target messenger RNA (mRNA), effectively shutting down protein production.Considerations for Optimal mRNA Targeting：Understanding mRNA Target Accessibility；Strategic siRNA Target Site Selection；Optimizing siRNA Sequence Composition；siRNA Thermodynamic Fine -Tuning for Maximum Efficacy.
[前沿资讯 ] 巴斯夫和云天化成功验证使用稳定性合成尿素肥料对温室气体的减排效果 进入全文
巴斯夫公司
2023 年，巴斯夫与中国化肥制造商云南云天化股份有限公司在中国启动了一项试点项目，以验证使用云天化公司所生产的、含巴斯夫力谋星® 脲酶抑制剂的稳定性尿素肥料所减排的二氧化碳当量。试点项目的结果证实，与未使用力谋星脲酶抑制剂处理的尿素肥料相比，云天化使用力谋星处理的肥料减少了约 46,584 吨二氧化碳当量的排放。该估算基于云天化在试点期间所销售的含力谋星的稳定性尿素。这些成果不仅有助于在中国践行气候智慧型农业倡议，还标志着项目的成功实施，为项目在全球范围内进一步推广奠定基础。
