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[学术文献 ] Utilizing plant synthetic biology to accelerate plant-microbe interactions research 进入全文
BioDesign Research
Plant-microbe interactions are critical to ecosystem resilience and substantially influence crop production. From the perspective of plant science, two important focus areas concerning plant-microbe interactions include: 1) understanding plant molecular mechanisms involved in plant-microbe interfaces and 2) engineering plants for increasing plant disease resistance or enhancing beneficial interactions with microbes to increase their resilience to biotic and abiotic stress conditions. Molecular biology and genetics approaches have been used to investigate the molecular mechanisms underlying plant responses to various beneficial and pathogenic microbes. While these approaches are valuable for elucidating the functions of individual genes and pathways, they fall short of unraveling the complex cross-talk across pathways or systems that plants employ to respond and adapt to environmental stresses. Also, genetic engineering of plants to increase disease resistance or enhance symbiosis with microbes has mainly been attempted or conducted through targeted manipulation of single genes/pathways of plants. Recent advancements in synthetic biology tool development are paving the way for multi-gene characterization and engineering in plants in relation to plant-microbe interactions. Here, we briefly summarize the current understanding of plant molecular pathways involved in plant interactions with beneficial and pathogenic microorganisms. Then, we highlight the progress in applying plant synthetic biology to elucidate the molecular basis of plant responses to microbes, enhance plant disease resistance, engineer synthetic symbiosis, and conduct in situ microbiome engineering. Lastly, we discuss the challenges, opportunities, and future directions for advancing plant-microbe interactions research using the capabilities of plant synthetic biology.
[学术文献 ] Chromosome-scale genome assembly of the fire blight resistant Malus fusca accession MAL0045, donor of FB_Mfu10 进入全文
Scientific Data
The wild apple, Malus fusca accession MAL0045, is highly resistant to fire blight disease, caused by the bacterial pathogen, Erwinia amylovora. A major resistance locus, FB_Mfu10 was identified on chromosome 10 of MAL0045 including other contributory loci on chromosomes 16, 4, and 15. Here, we report a chromosome-scale genome assembly of MAL0045 to facilitate the studies of its fire blight resistance. PacBio sequencing and Illumina sequencing for Hi-C contig anchorage were employed to obtain the genome. A total of 669.46 Mb sequences were anchored onto 17 chromosomes, taking up 99.75% of total contig length. Contigs anchored onto chromosomes were further ordered and orientated, where a total of 637.67 Mb sequences were anchored onto chromosomes in proper order and orientation, resulting in a final anchoring ratio of 95.25%. The BUSCO score of this assembly is 97.46%. Further, a total of 47,388 genes were predicted via ab initio, homology-based, and RNAseq methodologies. The availability of this genome will facilitate functional and comparative genomics studies, especially about the donors of fire blight resistance in Malus.
[前沿资讯 ] 罗氏制药中国宣布投资20.4亿人民币在上海新建生物制药生产基地 进入全文
上海市人民政府外事办公室
5月8日，罗氏制药中国宣布投资20.4亿元人民币，用于在上海新建生物制药生产基地。当天投资项目启动仪式举行。作为上海市市长国际企业家咨询会议成员企业之一，罗氏此次加码投资旨在通过强化企业在华供应链和本地化生产布局，全面强化端到端的完整医药价值产业链，再次彰显了全球头部企业继续深耕中国市场、融入上海建设发展的长期承诺。 新项目用地约53亩，建筑面积约2万5千平方米，位于上海浦东新区张江高科技园区。该项目预计将于2029年正式落成，2031年正式投产。罗氏将可持续发展理念贯彻于新基地的建设和运营之中。新生产基地的建设将采用国际领先的生产工艺、100%采用绿色电力。该基地将用于罗视佳®（法瑞西单抗注射液）的本地化生产，不断满足中国患者对于创新疗法的需求。 全新生物制药生产基地建成后，将成为罗氏制药在中国的第二个创新药物生产基地，与位于百米之外的罗氏制药中国区总部现有生产基地协同运作，共同为中国患者提供创新药品。早在1994年，罗氏作为第一家跨国药企入驻浦东张江。1997年，罗氏在上海总部园区的生产车间正式建成投产，并于2005年在华建成了高致敏生产车间。20年来，这一生产基地严格遵循GMP规范，确保生产环境的严格控制，加速满足中国患者对高质量药品的需求。2024年，罗氏实现了抗流感创新药速福达®（玛巴洛沙韦）的本地化生产，快速应对流感高发季中国流感患者的需求。
[学术文献 ] Bioremediation of complex organic pollutants by engineered Vibrio natriegens 进入全文
Nature
Industrial wastewater, petroleum pollution and plastic contamination are significant threats to global marine biosecurity because of their toxic, mutagenic and persistent nature1. The use of microorganisms in bioremediation has been constrained by the complexity of organic pollutants and limited tolerance to saline stress2. In this study, we used synthetic biology to engineer Vibrio natriegens into a strain capable of bioremediating complex organic pollutants in saline wastewater and soils. The competence master regulator gene tfoX was inserted into chromosome 1 of the V. natriegens strain Vmax and overexpressed to enhance DNA uptake and integration. Degradation gene clusters were chemically synthesized and assembled in yeast. We developed a genome engineering method (iterative natural transformation based on Vmax with amplified tfoX effect) to transfer five gene clusters (43 kb total) into Vmax. The engineered strain has the ability to bioremediate five organic pollutants (biphenyl, phenol, naphthalene, dibenzofuran and toluene) covering a broad substrate range, from monocyclic to multicyclic compounds, in industrial wastewater samples from a chlor–alkali plant and a petroleum refinery.
[前沿资讯 ] BioLumic Lighting Up Seed Innovation 进入全文
seedworld
BioLumic, a 2025 runner-up in the Seed World Global Innovation Showdown, has created a groundbreaking seed trait platform powered by light. Its technology, which activates traits using short, targeted bursts of UV and visible light, is not only transforming how seeds grow — it’s transforming how seed companies think about innovation. “We’re controlling gene expression with light,” Wargent explains. “We’re activating entire pathways that already exist in the plant, and we’re doing it instantly. There’s no gene editing, no chemicals, and no regulatory delay.” This approach, known as xTrait™ (short for Genetic Expression Trait) technology, taps into photomorphogenesis — plants’ natural response to light that drives development throughout the lifecycle. With Light Signal Recipes™, BioLumic uses brief, precise combinations of UV light as a natural programming language for plants that can boost root mass, increase yield, improve plant immunity and even reduce methane emissions in livestock feed crops. These treatments don’t alter DNA. Instead, they awaken what’s already there.
[前沿资讯 ] Harnessing the Power of Pollen Quality for Improved Seed Production and Breeding 进入全文
seedworld
Enter Amphasys, a pioneering company at the forefront of agricultural innovation. Their cutting-edge technology is revolutionizing how breeders and seed producers assess pollen quality, offering a fast, easy-to-use tool that delivers precision insights. This capability is significant, especially as the agricultural landscape grows increasingly competitive and complex. High-quality pollen is indispensable for effective pollination and achieving optimal seed sets. When it comes to hybrid breeding — often a more expensive and resource-intensive endeavor — pollen health can make or break production outcomes. The reality is that abiotic stressors can wreak havoc on pollen viability; even minor disruptions can hinder the crucial journey from anther to stigma. This is where Amphasys’ technology becomes invaluable, providing data that allows breeders to make informed choices about optimizing crop placement and fine-tuning female-to-male ratios. By determining the viability threshold for full seed set, Amphasys empowers seed producers to develop precise production patterns, particularly crucial for managing low-performing pollinators. Furthermore, the technology supports the development of effective storage protocols, ensuring that pollen maintains its viability for as long as necessary. The implications of these advancements are far-reaching. As growers leverage detailed insights into pollen characteristics, they can significantly enhance their decision-making processes, leading to improved seed yields and crop performance. In an era where food security looms as a critical challenge, this knowledge transforms how the agricultural sector approaches production — making it more efficient, sustainable, and responsive to environmental demands.
