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[学术文献 ] Computational design of serine hydrolases 进入全文
science
The design of enzymes with complex active sites that mediate multistep reactions remains an outstanding challenge. With serine hydrolases as a model system, we combined the generative capabilities of RFdiffusion with an ensemble generation method for assessing active site preorganization to design enzymes starting from minimal active site descriptions. Experimental characterization revealed catalytic efficiencies (kcat/Km) up to 2.2x105 M−1 s−1 and crystal structures that closely match the design models (Cα RMSDs < 1 Å). Selection for structural compatibility across the reaction coordinate enabled identification of new catalysts in low-throughput screens with five different folds distinct from those of natural serine hydrolases. Our de novo approach provides insight into the geometric basis of catalysis and a roadmap for designing enzymes that catalyze multistep transformations.
[前沿资讯 ] Startup grows egg proteins in potato fields 进入全文
nature biotechnology
Molecular farmers Maya Sapir-Mir (left) and Raya Liberman-Aloni are taking a global culinary favorite and transforming it into a low-cost bioreactor to manufacture egg protein. They set up PoLoPo in 2022 to engineer potato plants to produce egg-white protein without the need for expensive bioreactors. The company, which is based in Ness Ziona, Israel, has begun its first field trial growing the protein-rich tuber.PoLoPo has also developed potatoes with enhanced production of the protein patatin, which is found naturally in the tuber. The PoLoPo team genetically tweaked the potato genome to express genes that shift the plant’s metabolism towards protein production and accumulation in tubers. The team is now seeking approval from the US Department of Agriculture for the patatin-rich potatoes. PoLoPo received backing from the German venture capital firm FoodLabs. Other genetically modified potatoes are already available for sale in the USA. J.R. Simplot, based in Boise, Idaho, is already selling genetically modified Russet Burbank, Ranger Russet and Atlantic potatoes, which were created to resist bruising and potato blight.
[政策法规 ] Engineering Tomorrow: DARPA’s Push into the Frontier of Synthetic Biology 进入全文
美国国防高级研究计划局 (DARPA)
DARPA aims to tackle precisely these scaling nightmares by infusing them with fresh tools. Picture an AI-powered design-build-test cycle that runs round the clock, generating tens of thousands of experimental variants in days. Such an approach demands custom-built platforms for lab automation, capable of operating at volumes and speeds beyond what any typical bench scientist can do. Koeris insists that the future of SynBio depends on different defaults for experimental volumes, frequencies, and data capture. Instead of shaping everything around a human with a pipette, we can build microfluidic or robotic systems that revolve around the optimum scale for the experiment. He wants to eliminate the “little weeds” that often trap researchers when they try to interpret gene expression networks or cellular behaviors one micro-liter at a time. A neural network, on the other hand, doesn’t bat an eyelid at millions of data points.
[政策法规 ] 湖南省人民政府办公厅印发《关于支持常德市合成生物制造产业高质量发展的若干措施》的通知 进入全文
湖南省人民政府办公厅
湖南省人民政府将常德市合成生物制造产业纳入全省重点产业规划予以重点支持，推动合成生物制造产业项目、技术、成果向常德市集聚。重点支持酶制剂、医药中间体及制药原料、动植保药物及制剂、未来食品及保健品、医美原料及制剂、生物基材料、天然产物及衍生物等领域发展，打造全国一流的合成生物制造产业新高地。支持常德市争创合成生物制造领域的国家级产业集群。支持常德市以合成生物制造为示范内容，创建省级新型工业化产业示范基地。支持各类创新主体积极承接国家级、省级合成生物制造领域重大科技项目或课题，开展合成生物制造领域基础研究、应用基础研究和关键核心技术攻关。对企业承担国家重大科技专项、重点研发计划、自然科学基金等重大项目，省财政按政策从科技专项资金中给予支持。省科技计划项目设置专题，支持合成生物制造领域技术创新。支持常德市筹建湖南省合成生物制造标准化技术委员会，开展合成生物制造标准体系建设。鼓励引进合成生物制造领域国内顶尖研发机构在常德市设立分支机构。支持企业联合高校、科研院所以及产业链上下游企业组建省级创新联合体，推进创新链、产业链融合。
[前沿资讯 ] Final piece in synthetic yeast puzzle delivered 进入全文
Macquarie University
Macquarie University researchers have worked with an international team of scientists to achieve a major milestone in synthetic biology by completing the creation of the final chromosome in the world's first synthetic yeast genome.This achievement represents the completion of the global Sc2.0 project to create the world's first synthetic eukaryotic genome from Saccharomyces cerevisiae (baker's yeast) and a new-to-nature tRNA neochromosome.Using cutting-edge genome-editing techniques, including the CRISPR D-BUGS protocol, the team identified and corrected genetic errors that impacted yeast growth. These changes restored the strain’s ability to grow on glycerol, a key carbon source, under elevated temperatures.
[科研项目 ] Enveda’s fusion of natural product insights and AI just got a boost with a new CFO at the helm and $130M in fresh capital 进入全文
Enveda公司
Strengthening Enveda’s momentum is the recently announced $130 million Series C funding round, led by Kinnevik and FPV, with participation from new and existing investors, including Baillie Gifford, Premji Invest, Lingotto Innovation, Lux Capital, Dimension Capital, True Ventures, Cresset Partners, The Nature Conservancy, and Henry R. Kravis. This round brings Enveda’s total funding to $360 million, fortifying its ability to advance its pipeline of 10 Development Candidates, additional discovery programs, and a state-of-the-art AI platform.
