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[前沿资讯 ] AI Action Plan a Critical Step for AIxBio Innovation, National Security, and Global Economic Competitiveness 进入全文
NSCEB
The National Security Commission on Emerging Biotechnology applauds the inclusion of AIxBio in the White House’s new AI Action Plan. The Action Plan includes directives designed to retain and regain U.S. leadership at the convergence of AI and biotechnology, including several actions the NSCEB recommended earlier this year. The NSCEB made four recommendations on AIxBio which are reflected in the AI Action Plan: Invest in AI-Enabled Science ；Build World-Class Scientific Datasets: AI-Ready Data ；Build World-Class Scientific Datasets: Genome Sequencing ；Invest in Biosecurity.
[科研项目 ] Netherlands: European boost for global food security: Dutch biotech Solynta gets €20 million EIB backing for highly disease resistant potato varieties 进入全文
EuropeanInvestment Bank
EIB lends €20 million to Dutch biotechnology company Solynta to develop potato seeds with strong resistance to disease and resilience to climate change. The focus of the EIB loan, which is supported under the European Commission’s InvestEU programme, is on the use of true potato seeds instead of traditional tubers for cultivation. Solynta’s technology holds promise of securing successful potato harvests and enhancing
[前沿资讯 ] 巴斯夫和云天化成功验证使用稳定性合成尿素肥料对温室气体的减排效果 进入全文
巴斯夫公司
2023 年，巴斯夫与中国化肥制造商云南云天化股份有限公司在中国启动了一项试点项目，以验证使用云天化公司所生产的、含巴斯夫力谋星® 脲酶抑制剂的稳定性尿素肥料所减排的二氧化碳当量。试点项目的结果证实，与未使用力谋星脲酶抑制剂处理的尿素肥料相比，云天化使用力谋星处理的肥料减少了约 46,584 吨二氧化碳当量的排放。该估算基于云天化在试点期间所销售的含力谋星的稳定性尿素。这些成果不仅有助于在中国践行气候智慧型农业倡议，还标志着项目的成功实施，为项目在全球范围内进一步推广奠定基础。
[学术文献 ] Advances in haplotype phasing and genotype imputation 进入全文
Nature Reviews Genetics
Haplotype phasing — to determine which genetic variants reside on the same chromosome — and genotype imputation — to infer unobserved genotypes — have become indispensable steps to improve genome coverage for genomic analyses such as genome-wide association studies. Several tools exist for haplotype phasing and genotype imputation, all of which have continuously evolved to accommodate the increasing sample sizes of genomic studies and rapidly improving sequencing technologies. To fully leverage these recent advances, researchers must deliberate several practical considerations, including tool choice, quality control filters, data privacy concerns and reference panel choice. Looking ahead, long-read sequencing technologies are poised to bring novel opportunities to this field and drive methodological development.
[学术文献 ] Escherichia coli with a 57-codon genetic code 进入全文
Science
The near-universal genetic code uses 64 codons to encode the 20 canonical amino acids and protein synthesis. Here we designed and generated Escherichia coli with a 4 Mb synthetic genome in which we replaced known occurrences of six sense codons and a stop codon with synonymous codons. The resulting organism, Syn57, uses 55 codons to encode the 20 canonical amino acids.
[前沿资讯 ] Mastering siRNA Design: The Art and Science of Precision Gene Silencing 进入全文
GenScript公司
In the dynamic landscape of personalized genetic medicine, small interfering RNA (siRNA) has emerged as a transformative tool, enabling researchers to silence disease-causing genes with unprecedented precision. siRNAs are powerful molecular tools that harness the cell's natural RNA interference (RNAi) pathway to silence specific genes. These short (i.e., ~20 to 24 nucleotides) double-stranded RNA molecules guide the cellular machinery to precisely degrade target messenger RNA (mRNA), effectively shutting down protein production.Considerations for Optimal mRNA Targeting：Understanding mRNA Target Accessibility；Strategic siRNA Target Site Selection；Optimizing siRNA Sequence Composition；siRNA Thermodynamic Fine -Tuning for Maximum Efficacy.
