1. Use formula compound (1) to deal with modulation sensitive disorders of one or more opioid receptors, or as a synthetic intermediary. Some compounds are particularly useful in the treatment of pain. Claim 1: a compound characterized by formula (1) or a salt or drug acceptable solution, wherein R 1 is hydrogen, oh, halogen, cyanogen, carboxi, or carbamate； or tar, alquenilo, tar, alcoxi, alqueniloxi, or tar, optionally substituted by 1, 2, or 3； Alternatives, each of which is independent of the hydrogen XI, halogen, halide group,amino, alkylamino, dialkylamino, carboxy, alkoxy, alkoxycarbonyl, aryl, heteroaryl, heterocycle, cycloalkyl, and cycloalkenyl, where aryl, heteroaryl, heterocycle, cycloalkyl, and cycloalkenyl are optionally substituted with 1, 2, or 3 R¹¹ᵃ groups selected independently； or -O-PG, where PG is a hydroxyl protecting group； R² is: (a) hydrogen or carboxamide； or (b) alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocycle, aryl, heteroaryl, (cycloalkyl) alkyl, (cycloalkenyl) alkyl, (heterocycle) -alkyl, arylalkyl, heteroarylalkyl, alkylcarbonyl, alkoxycarbonyl, (arylalkyl) -carbonyloxycarbonyl or (heteroaryl-alkoxy) carbonyl,Any of these alternatives can be replaced by one, two or three alternatives, each of which is independently selected from the group of hydrogen Xi, tar, halogen, halotar, ammonia, leasing, diallamino, carboxi, alcoxi, alcoxi carbonilo, arilo, heteromorphic, heterocyclic, cyclopentadiene and cyclopentadienyl ester, Among them, arilo, heterocyclic, cyclopentadiene and cyclopentadiene can be selected independently by 1, 2, or 3 r74191； R 3 is hydrogen, oh, or halogen； or alcoxi, rental, or diaklamino, any of which can be replaced by 1, 2, or 3 substitutes,Each group was selected independently, including hydroxyl, halogen, halogen, ammonia, taxi, diallamino, carboxi, alcoxi, alcoxicarbonilo, arilo, heterogeneous, cyclopentadiene, cyclopentadiene and cyclopentadiene, among which, arilo, heterogeneous, heterocyclic, cyclo
