Compounds used to treat or prevent type II diabetes, carcinogenicity, and kidney disease. Claim 1: formula compound (1),Among them, R1 and R3 form an isomerized cyclopropyl with carbon atom and attached nitrogen atom； R2 is h, tar, halogenated tar, cyclopropyl Lu, halogenated cyclopropyl Lu, cyclopropyl clalquilo, halogenated cyclopropyl dragon, phenyl or phenyl substitute, a. To replace phenyl with one or three substitutes selected from asphalt, hydroxide, halotar, cyclopentyl, propoxy, haloxy, halogen, hydrogen Xi and cyanogen； r83408es h, tar or cyclopentadiene； W is the link, O -,- yes.-No. 83099--C (O) --S (O) --C (o) - No. 83099-o-cr8310； No. 8311；R8309es h, hydrocarbyl or cyclopentyl； r8310a and r8311811 are independent of H, hydrocarbyl or cyclopentyl； a is a phenyl substitute, sulfur fluorine substitute, benzo sulfur phosphorus substitute, balance substitute, in which substituted phenyl, sulfur fluorine substitute, Substituted benzothion with r831222；R8313 and r183044；B cyclopentadiene glycol substitute, cyclopentadiene substitute, pyridine substitute, phenyl substitute, thiophene substitute, benzothione substitute, tylopine substitute, cyclopentadiene substitute, pyridine substitute, phenyl substitute, thiophene substitute, benzothione substitute Replaced by R1,R1 and R3；R8322,R8313,R se selecciona independientemente de entre H alquilo alquenilo alquinilo hidroxialquilo haloalquilo hidroxihaloalquilo cicloalquilo cicloalcenil cicloalquilalquilo cicloalquenilalquilo cicloalquilalcoxi cicloalcoxi cicloalcoxialquilo cicloalquilalcoxialquilo alcoxi alcoxialquilo haloalcoxi haloalcoxialquilo alcoxialcoxi alcoxialcoxialquilo fenilo fenilo sustituido piridinilo piridinilo sustituido hal geno hidroxi ciano aminosulfonilo sustituido aminocarbonilo sustituido amino sustituido y aminoalquilo sustituido en los que aminosulfonilo substituted amino and substituted aminoalkyl are substituted on the nitrogen atom with one to two substituents independently selected from hy
