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2、 Sulfur dioxide and sulfur and their application
专利权人:
F. HOFFMANN-LA ROCHE AG
发明人:
申请号:
ARP180103157
公开号:
AR113811A1
申请日:
2018.10.30
申请国别(地区):
AR
年份:
2020
代理人:
摘要:
1. Claim 1: a formula compound (1) or a medically acceptable salt, wherein R1 is selected from tenant c83218331832626;cycloquilo C833238832626;C832222-(cycloquilo C833238331832626),Alcoxi C832188331636262;Halogenated tar c832183531832626,Haloalcoxy C83218C833316A3;1.C832183318326N-N(RN)8322;e. Isomerization of 4 to 8 members of phenyl, benzene, isocyclic propylene and 5 to 6 members, in which R1 can be replaced by one or two substitutes selected from the halogen group, namely c8321i833183226 tar;cycloquilo C833238832626;Alcoxi C832188331636262;Halogenated tar c832183531832626,Haloalcoxy C83218C833316A3;1.C832183318326N-N(RN)8322;Hydroxyl group, hydroxyl group;Ciano,Cianoal,Cianoal Quilo C832183231;(c)8333O°-8334358343Q75122;83058343834338C83218331832626;1. Phenyl, benzene, ch83222 - (cyclo-c8332331-832626);a. Five to six members were heterosexual, ch. 83222 - (5 to 6 members were heterosexual);N is equal to 0, 1 or 2; the choice of each square kilometer is independent of group c83218331832626;cycloquilo C833238832626;a. Alcox c83321218c83331-83226 and halogeodilo c83218833126;Or two R2 and their connected nitrogen atoms form a heterocyclic ring with four or six members; ring a and ring B combine to form a multi ring ring ring system, in which ring a is a five member heteroaromatic ring, and its only heteromorphic atom, Whether it is (I) two or three nitrogen atoms, (II) one nitrogen atom and one oxygen atom, or (III) one nitrogen atom and one sulfur atom; in this case, the ring a is replaced by a carbon atom, consisting of a substitute selected from the components consisting of fluoride, chlorine, methyl and sulfur trifluoride;(b) Rby is a member from 1 to 4, and rby is a member from 1 to 2, or RBP is a member from 1 to 2, or RBP is a ring from 1 to 2, or RBP is a member from 1 to 4; rby is a member from 1 to 4, and Rb P is a member from 1 to 2, or RBP is a ring from 1 to 2; R3 ° 74955 and 7491 / m3 and R3 ° 74955,(a) When the product exists, it should be selected
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