BERND BUETTELMANN,SIMONA M. CECCARELLI,HOLGER KUEHNE,BERND KUHN,WERNER NEIDHART,ULRIKE OBST SANDER,HANS RICHTER
申请号：
ARP130103210
公开号：
AR092496A1
申请日:
2013.09.10
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
Compounds used to treat carcinogenic, tumor, kidney and liver diseases. 1. Requirement 1: formula compound (1),Among them, R1 and R2 are from h, asphalt, halotars, alcohy, alcohy, haloalquilo, cycloclalquilo, halocyclopedia, halocyloquilo, halocylo clalquilo, arilo alternative, arilalquilo alternative, isocyclic propene alternative, isocyclic clalqui alternative, isocyclic allylene alternative, isocyclohexane alternative, heteromorphic alternative, e. Changed to r83088；Rs83099a and r18310a,and said substituted aminocarbonyl is substituted on the nitrogen atom by one or two substituents independently selected from H, alkyl, cycloalkyl, haloalkyl, alkylcycloalkyl cycloalkylalkyl, alkylcycloalkylalkyl, hydroxyalkyl and alkoxyalkyl； R³ is a substituted aryl, substituted arylalkyl, substituted heterocycloalkyl, substituted heterocycloalkylalkyl, substituted heteroaryl or substituted heteroarylalkyl, said substituted aryl, substituted arylalkyl, substituted heterocycloalkyl, substituted heterocycloalkylalkyl, substituted heteroaryl and substituted heteroaryl.R1 831222 and R1 8313；h. R8308es h or asphalt； r83090 and r8310e are independently selected from h, asphalt and cyclopentadiene； r8311es h, asphalt or cyclopentadiene； a No. 831222 or cr8313； r183044；E is nhr1 or Cr13；R831222 and R1 are independently selected from h, tar, halotars, cyclomethyllu, halomethyllu, cyclomethylcarat or halomethyllajilu； r8313；R830404,R2 and R1 3 are independently selected from h, halogen, asphalt, halogen and cyclopentadiene； or r83099 and R1 form a cyclopentadiene compound together with the carbon atoms connected with them, replacing cyclopentadiene, replacing arilo, replacing non cyclopentadiene, replacing isocyclopentadiene, replacing isocyclopentadiene, replacing isocyclopentadiene, replacing isocyclopentadiene, replacing cyclopentadiene, 1. Use r83044 to replace the substituted cyclopropene (cyclopropene), and use R2 and / or R2 to replace it；However, if r83099 and R1 square, together
