CHRISTINE E. BROTHERTON-PLEISS,HUIFEN CHEN,SHAOQING CHEN,ZHI CHEN,SHAWN DAVID ERICKSON,ANTHONY ESTRADA,KYUNGJIN KIM,HONGJU LI,JOSEPH P. LYSSIKATOS,ALLEN JOHN LOVEY,YIMIN QIAN,SUNG SO,PETER MICHAEL SAU
申请号：
ARP130103449
公开号：
AR092684A1
申请日:
2013.09.26
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
A pharmaceutical component that contains these compounds. These compounds may help in the treatment of ptra1 diseases and conditions such as pain. Claim 1: consists of formula (1),10. Y, Z are independent C, ch or N； R1 is unsubstituted phenyl, single substituted phenyl or bisust with halogen or - CN independently, 5 or 6 unsubstituted heterocycles, or 5 or 6 heterocycles with lower pitch, halogen or halide； R2 It is selected from hydrogen, deuterium, low tar, halogenated tar, cyclopentanediol, alcoxi, oxitanil, phenyl and a isomerized ring of 5 or 6 elements, including lower tar, halogenated tar and cyclopentanediol,The alternatives Aoxi or oxetanio are replaced by deuterium, in which case, the phenyl and isomerized rings of the five or six elements are replaced by lower tar, halogen, deuterium or halogen respectively； R3 and R3 are selected respectively, In a group consisting of hydrogen, deuterium, halogenated tar, cyclopentadiene and lower tar, the halogenated tar, cyclopentadiene and lower tar can be selectively replaced by deuterium, F, Cl, Br, hydroxy or alcoxi, or R3 and R3 together with the attached carbon to form a 3,4 cyclopentadienyl group, 5 or 6 alternative text to deuterium,F, Cl, Br, hydroxyl or alkoxy； R⁴ is hydrogen or lower alkyl； R⁵ is trifluoromethylphenyl, trifluorometilpiridinilo, trifluorometilpiridazinilo, trifluorometilpirimidinilo, azetidino, pyrrolidino, cycloalkyl, piperidino, pyrrolidino-pyrimidinyl heterocycle, heterociclopirimidinilo, heterocycle-pyridinyl, heterocycle-pyridazinyl, heterocycle-pyrazinyl, cicloalquilpirimidinilo, cycloalkyl-pyridinyl, pyridazinyl cycloalkyl, cycloalkyl- pyrazinyl or trifluoromethylpyrazinyl, in which any azetidinyl, pyrrolidino, cycloalkyl, heterocycle and piperidino is optionally substituted with lower alkyl, halogen, trifluoromethyl, trifluoromethoxy or trifluoromethylthio；R8310 is hydrogen, halogen or alcoxi； or a pharmaceutically acceptable salt.Composiciones farmacéuticas que contienen dichos comp
