DYATKINA NATALIA,WANG GUANGYI,RAJWANSHI VIVEK,BEIGELMAN LEONID,SMITH DAVID BERNARD,BLATT LAWRENCE
申请号：
ARP110103444
公开号：
AR083069A1
申请日:
2011.09.21
申请国别(地区):
AR
年份:
2013
代理人:
摘要：
Methods for the synthesis of nucleoside phosphorylamine like data and methods for the treatment of diseases and / or diseases, such as viral infections, cancer and / or parasitic diseases, use similar nucleotide phosphorylamine data. B1 is an optional heterocyclic group or optional heterocyclic group, which is replaced by one or more protected amino groups； R1 is an amino acid or an alternative amino acid ester derivative attached to an alternative；R2 is selected from a group of structures consisting of an alternative arilo, an alternative isomer and an alternative isomer； R3a and R3b are independent of hydrogen, an alternative C1-6 tar, and an alternative c2-6 alquinio, Alternative c12-6 asphalt, alternative C1-6 halide and aril (C1-6 asphalt)1. The condition is that at least one R3a and R3b are not hydrogen； or R3a and R3b together form a group selected from the group, which includes an optional C3-6 cyclopentadiene, an optional C3-6 cyclopentadiene, an optional alternative C3-6 cyclopentadiene, and an optional alternative C3-6 heterogeneity； R4 is hydrogen； R5 is selected from the hydrogen group, - or9 and - OC (= O) R10； R6 is selected from the hydrogen group, - halogen, - or11 and - OC (= O) R12； or R5 and R6 are two oxygen atoms and are combined by one carbon group； R7 is selected from the hydrogen, halogen and alternative C1-6 tar group,-R13 and - OC (= O) R14； R8 is hydrogen or a selectively substituted C1-6 tar； R9, R11 and R13 are selected independently of the category consisting of hydrogen and a selectively substituted C1-6 tar； R10, R12 and R14 are selected independently of a group consisting of a selectively substituted C1-6 tar and a selectively substituted C3-6 cyclopentyl tar； provided, however, that a formula compound (1) cannot have a structure selected from a group of formulas, including any group of formulas (2).Métodos de sintetización de fosforoamidatos análogos de nucleótidos y métodos de tratamiento de enfermedades y/o afecciones tales como
