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Anti hepatitis B virus preparation
专利权人:
ENANTA PHARMACEUTICALS; INC.
发明人:
OR, YAT SUN,SUH, BYUNG,CHUL - CAO, HUI,KASS, JORDEN,LI, WEI,PENG, XIAOWEN,GAO, XURI,QIU, YAO-LING
申请号:
ARP180103556
公开号:
AR113913A1
申请日:
2018.12.05
申请国别(地区):
AR
年份:
2020
代理人:
摘要:
This table shows the formula compound (1),They can also be used as antiviral agents. 3. This document also covers pharmaceutical ingredients including the above compounds, CA person with Hexabromodiphenyl infection The current situation also relates to the treatment of Hexabromodiphenyl infection in one subject by the use of drug components including the current compounds. 1. Claim 1: a compound represented by (1) formula or acceptable table saltAlternative a is an arilo alternative or a heteromorphic alternative; B is selected from hydrogen, halogen, CN, alternative alternatives c831832626 and cyclopentadiene c8332383331; X is an optional alternative or an optional variant; and es-c (o) nr.r,-C(O)Or1,e. Among them, alquenilo c8332183316c8328331c83838331c83328328, c83283318328 and cyclocoquilo c8332383318383318328 were selected independently from the hydrogen group; 3-a-8 heterocyclic ring, substituted, substituted, heteromorphic, substituted; or, R1 and R2 are combined with nitrogen atoms to form a 3-a-8 heterocyclic ring, substituted;R and Z are combined with carbon atoms to form a 3-8-member cyclopentadiene, a 3-8-member cyclopentadiene, or a 3-8-member aperiodic ring, or a 3-8-member aperiodic ring, provided that, in the case of substituted arilo being replaced or substituted heteromorphic arilo being replaced, The carbon atoms added together by R and Z do not form formula compounds (2) or (3),1. It contains c8330909, c833218331-8328 selective substitution, alquenilo c831832228 selective substitution, c8322833183838331838383838331, selective substitution, ring ring ring c833238331832883, alternative 3-a8, optional substitution and arilo substitution; Alternative C (o) R1 cubic-C(O)Or 3,-C(O)Nr°1 R8308;-S(O)8322;r3,o-S(o)8322;NrºR830808;e. In each substance, R 3 ° and r183088 are hydrogen, c83218c832883838328, alquenilo, c83228331832883838328, c83283318328, c8332383318328 and 3-A 8-optional substitution members, respectively; Arilo alternative or alternative.La p
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