The present invention relates to compounds of formula (I) in the form of base or acid addition salts, hydrates or solvates. The present invention also relates to methods of preparing the compounds and their therapeutic uses.<；Formula I>；WhereX 1 , X 2 , X 3 , X 4 , Z 1 , Z 2 , Z 3 , Z 4 and Z 5 are independently of each other a hydrogen or halogen atom, or C 1 -C 6 -alkyl, C 3 -C 7- Cycloalkyl, C 1 -C 6 -fluoroalkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -fluoroalkoxy, cyano, C (O) NR 1 R 2 , nitro, NR 1 R 2 , C 1 -C 6 -thioalkyl, -S (O) -C 1 -C 6 -alkyl, -S (O) 2 -C 1 -C 6 -alkyl, SO 2 NR 1 R 2 , NR 3 COR 4 , NR 3 SO 2 R 5 or an aryl group； X 5 represents a hydrogen or halogen atom or a C 1 -C 6 -alkyl or C 1 -C 6 -fluoroalkyl group； R represents an optionally substituted 4-, 5-, 6- or 7-indolyl group； Y represents a hydrogen atom or a C 1 -C 6 -alkyl group； n is 0, 1, 2 or 3； R 1 and R 2 independently of one another represent a hydrogen atom or a C 1 -C 6 -alkyl, C 3 -C 7 -cycloalkyl, C 3 -C 7 -cycloalkyl-C 1 -C 3 -alkyl or aryl group ； Or R 1 and R 2 together with the nitrogen atom to which they are attached form an azetidine, pyrrolidine, piperidine, azepine, morpholine, thiomorpholine, piperazine or homopiperazin group, which group is C 1 Optionally substituted by a -C 6 -alkyl, C 3 -C 7 -cycloalkyl, C 3 -C 7 -cycloalkyl-C 1 -C 3 -alkyl or aryl group； R 3 and R 4 independently of one another represent a hydrogen atom or a C 1 -C 6 -alkyl or aryl group； R 5 represents a C 1 -C 6 -alkyl or aryl group.TRPV1, VR1, antagonist activity, N- (1H-indolyl) -1H-indole-2-carboxamide본 발명은 염기 또는 산 부가염, 수화물 또는 용매화물 형태의 화학식 I의 화합물에 관한 것이다. 또한, 본 발명은 상기 화합물의 제조 방법 및 이의 치료적 용도에 관한 것이다.<；화학식 I>；상기 식에서,X1, X2, X3, X4, Z1, Z2, Z3, Z4 및 Z5는 서로 독립적으로 수소 또는 할로겐 원자, 또는 C1-C6-알킬, C3-C7-시클로알킬, C1-C6-플루오로알킬, C1-C6-알콕시, C1-C6-플루오로알콕시, 시아노, C(O)NR1R2, 니트로, NR1R2, C1-C6-티오알킬, -S(O)-C1-C6-알킬, -S(O)2-C1-C6-알킬, SO2NR1R2, NR3COR4, NR3SO2R5 또는 아릴기를 나타내고； X5는 수소 또는 할로겐 원자, 또는 C1-C6-알킬 또는 C1-C6-플루오로알
