LIN, IVAN JYH BIAU,林志彪,林志彪,HSU, TINA H. T.,徐筱婷,徐筱婷,CHOU, SHIU HUEY,周秀慧,周秀慧
申请号：
TW105136036
公开号：
TWI614245B
申请日:
2016.11.04
申请国别(地区):
TW
年份:
2018
代理人:
摘要：
The present application provides a composition comprising a core formed by gold nanoparticle, a compound of Formula (I): wherein dashed lines in Formula (I) represent (i) with or without an attachment of benzol group, (ii) a delocalized bond where shown within a ring R1 is hydrogen or a halogen R2 is a linker selected from C6-20 alkyl or polyethylene glycol R3 is C1-20 alkyl, C1-20 substituted alkyl, hexadecanyl amido, pyridinyl, benzyl or pyrimidinyl and a compound of Formula (II): wherein dashed lines, R1, R2 and R3 are defined as in Formula (II), and M is a metal. The composition has an inhibition ability against a cancer.本發明係提供一種組成物,包括一由金奈米顆粒所形成之核、式(I)所示之化合物、及式(II)所示之化合物:其中,該式(I)及(II)之虛線係分別表示:(i)具有或不具有苯基之附加、(ii)於一環中之非定域鍵;R1為氫或鹵素;R2為一連接子,係選自C6-20烷基或聚乙二醇;R3為C1-20烷基、C1-20經取代之烷基、十六烷基醯胺基、吡啶基、芐基或嘧啶基;及M為金屬,係選自金(Au)、銀(Ag)、鈀(Pd)、鉑(Pt)、銥(Ir)或銠(Rh)。該組成物能抑制癌症。
