A compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof is provided. In formula (I), R1, R2 and R3 are each, independently, hydrogen, amino, nitro, halogen, hydroxyl, C1-C6 alkoxy, carboxylic acid, C1-C6 alkoxycarbonyl, C1-C6 amino, C1-C6 aminocarbonyl, C1-C6 alkyl, branched C1-C6 alkyl, C1-C6 cycloalkyl, C1-C6 heterocyclic, aryl or heteroaryl, provided at least one of R1 and R3 is an amino group. A linker-drug and a ligand-drug conjugate including the compound are also provided.本揭露提供一種具有式(I)的化合物或其藥學上可接受的鹽類或溶劑化物。式(I)中,每一R1、R2與R3獨立地為氫、胺基、硝基、鹵素、羥基、C1-C6烷氧基、羧基、C1-C6烷氧基羰基、C1-C6胺基、C1-C6胺基羰基、C1-C6烷基、C1-C6分支型烷基、C1-C6環烷基、C1-C6雜環基、芳基或雜芳基,R1與R3至少其中之一為胺基。本揭露亦提供一種包含該化合物的連接子-藥物及配體-藥物耦合體。
