SIT, RAKESH KUMAR,PINCHMAN, JOSEPH ROBERT,BUNKER, KEVIN DUANE,HOPKINS, CHAD DANIEL,HEGDE, SAYEE GAJANAN,SLEE, DEBORAH HELEN,HUANG, PETER QINHUA
申请号：
ARP170100788
公开号：
AR108011A1
申请日:
2017.03.30
申请国别(地区):
AR
年份:
2018
代理人:
摘要：
Compounds of indopirimidina derivatives that can be used in the treatment of breast cancer. In addition, it also provides intermediary services for its synthesis. 1. Claim 1: a formula compound (1),Or a medically acceptable salt, where x1,Y1 and Z1 are independent of each other C or N, but the first condition is that there is at least one x1,Y1 and Z1 are n, but the second condition is that each x1,Y1 and Z1 are neutral, but there are three conditions, that is, two dotted lines represent double combination, but the fourth condition is the value of x1,Y1 and Z1 can be respectively satisfied by matching with selected h and R2 substitutes；X² is O, NH or S； A¹ is selected from the group consisting of an optionally substituted cycloalkyl, an optionally substituted aryl, an optionally substituted heteroaryl and an optionally substituted heterocyclyl； R¹ is selected from the group consisting of an optionally substituted C₁₋₆ alkyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted heterocyclyl, an optionally cycloalkyl (C₁₋₆ alkyl) substituted, an optionally substituted cycloalkenyl (C₁₋₆alkyl), an optionally substituted aryl (C₁₋₆alkyl),an optionally substituted heteroaryl (C₁₋₆alkyl) and an optionally substituted heterocyclyl (C₁₋₆alkyl)； R² and R³ are each independently selected from the group consisting of hydrogen, halogen, an optionally substituted C₁₋₆ alkyl and an optionally substituted C₁₋₆ haloalkyl； or R² and R³ together with the carbon to which R² and R³ are attached form an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl or an optionally substituted heterocyclyl； R⁴ and R⁵ are each independently selected from the group consisting of hydrogen, halogen,e. With r830808 and r83099a, together with the carbon contained in r830808 and r83099a, an alternative cyclopentadiene, an alternative cyclopentadiene, or an alterna
