ASSEMBLY BIOSCIENCES, INC.;INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
发明人:
WILLIAM TURNER,SAMSON FRANCIS,HANS MAAG
申请号：
ARP160102820
公开号：
AR106041A1
申请日:
2016.09.15
申请国别(地区):
AR
年份:
2017
代理人:
摘要：
Some of them provide compounds with the characteristics of hepatitis C serum of hepatitis B virus, and also provide treatment methods for virus infection such as hepatitis B, including providing a compound for transmission to patients in need. Requirement 1: a compound represented by formula (1),Places selected from Group s (o) 696；C 3DO C (R)NRY and O where y is 0, 1, or 2； R¹¹ is H or C₁₋₆alkyl, RY is selected from the group consisting of H, methyl, ethyl, propyl, proprenyl, butyl, phenyl and benzyl, where RY, when it is not H, may be optionally substituted with hydroxyl； RZ is selected from the group consisting of H, methyl, ethyl, propyl, phenyl and benzyl； Rᵐ ’and Rᵐ are independently selected from each other from the group consisting of H and C₁₋₆alkyl (optionally substituted with one, two or three substituents each independently selected from halogen and hydroxyl)；R²¹ is selected in each case from the group consisting of H, halogen, and C₁₋₆alkyl； q is 0, 1, or 2； R²² is selected in each case from the group consisting of H, halogen, hydroxyl, nitro, cyano, carboxy, C₁₋₆alkyl, C₂₋₆alkenyl, C₂₋₆alquinyl, C₁₋₆alkoxy, NR’R ’’,-C (O) -C alquilo -C (O) -C alcoxi -C (O) -NR R-C (3DNH) -NR RX2-phenyl (optionally replaced by 1, 2 or 3 r8310 substitutes)；3. Phenyl (alternative to 1, 2 or 3 alternatives represented by r8310)；1. Heterosexual, 5-6 members of single ring (alternative to 1, 2 or 3 substitutes represented by r8310)；9-10 members of the bicyclic heterosexual (alternative to 1, 2 or 3 r8311 representatives)；C₃₋₆cioloalkyl, -S (O) ʷ-C₁₋₆alkyl (where w is 0, 1 or 2),-S (o) 695-nr'r '(W is 0, 1 or 2),Y-nr '- S (o) 695 (W is 0, 1 or 2)；In each case, R 'is selected separately from h, methyl, ethyl and propyl； R' 'is selected separately from h, methyl, ethyl, propyl, butyl, - C (o) - methyl and - C (o) - ethyl or R' and R '', together with the attached nitrogen, they can form a heterocycle of 4-7 members； each member can form 4-7 members. In r830808,R83099,R8310,R831
