ASSEMBLY BIOSCIENCES, INC.;INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
发明人:
MARK BURES,HANS MAAG,LEE ARNOLD,BILL TURNER
申请号：
ARP160102816
公开号：
AR106037A1
申请日:
2016.09.15
申请国别(地区):
AR
年份:
2017
代理人:
摘要：
Some of them provide compounds with the characteristics of hepatitis C serum of hepatitis B virus, and also provide treatment methods for virus infection such as hepatitis B, including providing a compound for transmission to patients in need. 1. Characteristic requirement 1: compound represented by formula (1) and selected from Group s (o) 696；C 3DO C (R)NRY and O where y is 0, 1, or 2； R¹¹ is H or C₁₋₆alkyl, RY is selected from the group consisting of H, methyl, ethyl, propyl, proprenyl, phenyl and benzyl, where RY, when not H, may optionally be substituted with hydroxyl； RZ is selected from the group consisting of H, methyl, ethyl, propyl, phenyl, and benzyl； Rᵐ ’and Rᵐ are independently selected from each other from the group consisting of H and C₁₋₆alkyl (optionally substituted with one, two or three substituents each independently selected from halogen and hydroxyl)；L is a bond or C₁₋₂alkylene (optionally substituted with halogen or C₁₋₂alkyl)；A is a 5-7 membered heterocyclic monocyclic or 5-6 membered monocyclic heteroaryl ring optionally substituted with one or two substituents selected from the group consisting of halogen, hydroxyl, cyano, C₁₋₆alkyl, C₂₋₆alkenyl, C₂₋₆alquinyl, C₁₋₆alkoxy, and NR'R ''；B selected from the phenyl group (optionally replaced by one, two or three alternatives expressed in cubic meters),Single ring heterosexuality of 5-6 members (optionally replaced by one, two or three substitutes in cubic meters),(b) 9-10 member bicycles (alternative to 1, 2 or 3 alternatives in square brackets)；R 'is selected from h, methyl, ethyl and propyl, respectively, among h, methyl, ethyl and propyl； R' is selected from h, methyl, ethyl and propyl, respectively, among h, methyl, ethyl and propyl (optionally substituted with hydroxyl),Butyl (optionally hydroxyl)-C (o) - methyl and - C (o) - ethyl, or R 'and R' 'together with the nitrogen attached to them, can form a heterocycle composed of 4-7 members, which can be replaced by one, two or more substitutes
