JANETA POPOVICI-MULLER,JEREMY TRAVINS,FRANCESCO G. SALITURO,JEFFREY O. SAUNDERS,RENE M. LEMIEUX,YONGSHENG CHEN
申请号：
ARP130104322
公开号：
AR093598A1
申请日:
2013.11.22
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
Compounds and compositions comprising compounds that inhibit glutaminase are described herein. Methods for employing compounds that inhibit glutaminase in the treatment of cancer are also described herein. Claim 1: A compound of the formula (1) or a pharmaceutically acceptable salt thereof, wherein X is an optionally substituted C₃₋₇ cycloalkylene； each W, Y and Z is independently -S-,-CH=- that is...-N=O-NH-But for each ring, at least one group W and Z is not = =；Each R1 and R2 is independent - nh832222,-N (R) -C (O) -R-C (O) -N (R) -R-N (R) -C (O) -O-R-N (R) -C (O) -N (R) -R o -N (R) -C (O) -SREach cubic meter is independent hydrogen, c8332131 asphalt or arilo； each cubic meter is independent c83331 asphalt.1. Arilo, heal arilo, aralquilo, hearlquilo, hearlquilo, cycloquilo, cycloaquilo, heatricilalquilo or heterocycle bicycles, each of which was replaced by r83099 0-3 times；Each r83099a is a separate lease of c832183318c83226；C₁₋₆ alkoxy,-O- (alquilen C) (alcoxi C)-O-heterocyclyl, C₁₋₆ thioalkoxy,C₁₋₆ haloalkyl,C₃₋₇ cycloalkyl,C₃₋₇ cycloalkylalkyl,Arilo, heterosexual, aralquilo, heterosexual, heterosexual, heterosexual, cyanide, halo, oxo oh ocf83233,-OCHF₂,-So832222 - (rent c8321)-No.8322；-N (R⁷) -C (O) - (C₁₋₆ alkyl),-C (O) N (R)-N (R⁷) S (O) ₁₋₂- (C₁₋₆ alkyl),-S (O) N (R)-N (R)- (alquilen C) -N (R)wherein said alkyl, C₁₋₆ alkoxy,-O- (alquilen C) (alcoxi C)-O-heterocyclyl, C₁₋₆ thioalkoxy,C₁₋₆ haloalkyl,C₃₋₇ cycloalkyl,C₃₋₇ cycloalkylalkyl,aryl, heteroaryl, aralkyl, heteroaralkyl, heterocyclylalkyl, heterocyclyl, -SO₂- (C₁₋₆ alkyl),-No.8322；-N (R⁷) -C (O) - (C₁₋₆ alkyl),-C (O) N (R)-N (R⁷) S (O) ₁₋₂- (C₁₋₆ alkyl),-S (O) N (R)-N (R⁷) ₂ or (C₁₋₆ alkylene) -N (R⁷) ₂ is optionally substituted 0-3 times with R⁸；(o) Two adjacent r83099 residues, together with the atoms attached to them, form a cyclopropyl or non cyclopropyl group； each r8310s is independent of hydrogen, fluorine and tar c83318326；-Oh, nh832222,-NH (CH)-N (CH₃) ₂ or C₁₋₆ alkoxy；each R⁷ is independentl
