Compounds represented by the general formula (1) or (100) have excellent inhibitory activities against cell adhesion and cell infiltration and are useful as therapeutic or preventive agents for various inflammatory and autoimmune diseases caused by the adhesion and infiltration of white blood cells, for example, inflammatory diseases of intestine (particularly ulcerative colitis or Crohn's disease), irritable bowel syndrome, rheumatic arthritis, psoriasis, multiple sclerosis, asthma, and atopic dermatitis. Formula (1) or (100) wherein R10 is optionally substituted cycloalkyl group or the like； R20, R21, R22 and R23 are each hydrogen, alkyl, alkoxy group, or the like； R30, R31 and R32 are each hydrogen, alkyl, oxo group, or the like； and R40 is optionally substituted alkyl group or the like.本發明之式(1)或(100)所示化合物係具有優異之細胞黏著抑制作用及細胞浸潤抑制作用、做為發炎症腸疾病(特別是潰瘍性大腸炎或克隆氏病)、過敏性腸症候群、風濕性調節炎、乾癬、多發性硬化症、氣喘、異位性皮膚炎等會引起白血球黏著及浸潤之各種發炎症性疾病及自行免疫疾病之治療或預防劑為有用者。；(1) (100)；(式中；R10示可被取代之環烷基等，R20~R23係示氫原子、烷；基、烷氧基等，R30~R32係示氫原子、烷基、氧基等、R40係示可被取代之烷基等)。
