Compounds useful as AMPK activators are provided. Formula: (wherein X is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cyclo Alkyl, substituted or unsubstituted cycloalkenyl or substituted or unsubstituted heterocyclyl, wherein R1 is hydrogen, halogen, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted Substituted acyl, substituted or unsubstituted carbamoyl, substituted or unsubstituted alkylthio, substituted or unsubstituted alkylsulfinyl, substituted or unsubstituted alkylsulfonyl or substituted or unsubstituted alkyloxycarbonyl, R2 is halogen, substituted Also Or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cyclo Alkenyl, substituted or unsubstituted heterocyclyl, etc., and R3 is halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted Substituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted heterocyclyl, and the like, and R4 represents hydrogen, halogen, hydroxy, cyano, Nitro, Carbo Shi, a substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, and the like.) The compound or a pharmaceutically acceptable salt, represented by.ＡＭＰＫ活性化剤として有用な化合物を提供する。式：（式中、Ｘは置換もしくは非置換のアルキル、置換もしくは非置換のアルケニル、置換もしくは非置換のアルキニル、置換もしくは非置換のアリール、置換もしくは非置換のヘテロアリール、置換もしくは非置換のシクロアルキル、置換もしくは非置換のシクロアルケニルまたは置換もしくは非置換のヘテロサイクリルであり、Ｒ１は水素、ハロゲン、シアノ、ニトロ、カルボキシ、置換もしくは非置換のアルキル、置換
