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Spirocyclic cyclohexane derivatives
专利权人:
Grünenthal GmbH
发明人:
Hinze, Claudia,Aulenbacher, Otto,Sundermann, Bernd,Oberbörsch, Stefan,Friderichs, Elmar,Englberger, Werner,Kögel, Babette-Yvonne,Linz, Klaus,Schick, Hans,Sonnenschein, Helmut,Henkel, Birgitta,Rose, Va
申请号:
ES10005484
公开号:
ES2587185T3
申请日:
2003.11.05
申请国别(地区):
ES
年份:
2016
代理人:
摘要:
Spirocyclic cyclohexane derivatives of the general formula I, ** Formula ** where R1 and R2 represent, independently of each other, H, branched or unbranched (C1-5) alkyl, saturated or unsaturated, unsubstituted, or CHO; or the groups R1 and R2 together represent CH2CH2OCH2CH2, CH2CH2NR11CH2CH2 or (CH2) 3-6; R11 being equal to H; or (C1-5) alkyl, in each case saturated or unsaturated, branched or unbranched, unsubstituted; R3 represents (C1-5) alkyl, in each case saturated or unsaturated, branched or unbranched, substituted simply or multiple or unsubstituted; (hetero) C3-8 cycloalkyl, in each case saturated or unsaturated, substituted simply or multiple or unsubstituted; aryl, in each case substituted simply or multiplely or unsubstituted; or aryl or (hetero) C3-8 cycloalkyl, in each case substituted in a simple or multiple or unsubstituted form, linked through a (C1-3) alkyl, in each case saturated or unsaturated, branched or unbranched; W represents NR4, O or S; R4 being equal to H, saturated or unsaturated (C1-5) alkyl, branched or unbranched, substituted simply or multiple or unsubstituted; or substituted or unsubstituted aryl; R5 represents (hetero) C3-8 cycloalkyl saturated or unsaturated, substituted simply or multiple or unsubstituted; aryl or heteroaryl substituted single or multiple or unsubstituted; or (hetero) C3-8 cycloalkyl or heteroaryl linked through a (C1-3) alkyl, in each case saturated or unsaturated, branched or unbranched, substituted simply or multiple or unsubstituted; R6 represents H; F, Cl, NO2, CF3, OR13, SR13, SO2R13, SO2OR13, CN, COOR13, NR14R15; (C1-5) alkyl saturated or unsaturated, branched or unbranched, substituted simply or multiple or unsubstituted; aryl substituted single or multiple or unsubstituted; or single or multiple or unsubstituted substituted aryl, linked through a (C1-3) alkyl, in each case saturated or unsaturated, branched or unbranched; R7, R8, R9 and R10 represent, independently of each other, H, F, Cl, Br, I, NO2,
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