Substituted compound of general formula (I) where L represents C (>； = O) or CH2； A and B are selected in each case, independently of each other, from the group consisting of N, NR100, O and S, where R100 is equal to H, (C1-6) alkyl, (C3-8) cycloalkyl, aryl, heteroaryl or (C3-8) cycloalkyl, aryl or heteroaryl linked through a (C1-6) alkylene group； b represents 0 or 1； c, d, e and f represent in each case, independently of each other, 0, 1 or 2； q represents 0, 1, 2 or 3； s represents 0, 1, 2 or 3； r represents 1, 2 or 3； B1 represents C (>； = O), S (>； = O) 2 or the group -C (>； = O) -N (R9), the nitrogen atom thereof being attached to the group R1； Q1 and Q2 represent in each case, independently of each other, C, CH or N； R1 represents (C1-6) alkyl, aryl, heteroaryl, -CH (aryl) 2, cycloalkyl (C3-8) or aryl, heteroaryl or cycloalkyl (C3-8) linked through a (C1-6) alkylene group, alkenylene (C2-6) or alkynylene (C2-6)； R2 represents H, (C1-6) alkyl, (C3-8) cycloalkyl, aryl, heteroaryl or (C3-8) cycloalkyl, aryl or heteroaryl linked through a (C1-6) alkylene group； R3a and R3b represent in each case, independently of each other, H, F, CF3, (C1-6) alkyl, (C3-8) cycloalkyl, aryl or heteroaryl, or represent (C3-8) cycloalkyl, aryl or heteroaryl linked to through an alkylene group (C1-6)； R3a and R3b, together with the C atom that binds them together, form a saturated ring is not substituted or substituted on one or more of the ring carbons, for example 1, 2, 3 or 4, with one or more, for example 1, 2, 3 or 4, substituents selected, independently from each other, from the group consisting of F, CF3, (C1-8) alkyl, O-C1-6 alkyl, OH, OCF3, aryl and heteroaryl, where the ring has 3, 4, 5 or 6 members, and may optionally include one or more, for example 1 or 2, oxygen atoms； or one of the groups R3a or R3b and R2, together with the N and C atoms that bind them, form a saturated ring unsubstituted or substituted in one or more, for example 1, 2, 3 or 4, of their carbon
