KIM, HYOUNG RAE,김형래,LEE, CHONG OCK,이정옥,RYU, JAE WOOK,류재욱,HA, JAE DU,하재두,CHO, SUNG YUN,조성윤,JUNG, HEE JUNG,정희정,HAN, SUN YOUNG,한선영,LEE, JONG KOOK,이종국
申请号：
KR1020120070944
公开号：
KR1020120100845A
申请日:
2012.06.29
申请国别(地区):
KR
年份:
2012
代理人:
摘要：
PURPOSE: A pharmaceutical composition containing pyridine derivative subsituted with multiple substituted benzoxazole is provided to prevent and treat abnormal cell growth diseases.CONSTITUTION: A pyridine derivative substituted with multiple substituted benzoxazole is denoted by chemical formula 1. A method for preparing the derivative or pharmaceutically acceptable salt thereof comprises: a step of substituting a compound of chemical formula 2 to prepare a compound of chemical formula 4 a step of cyclizing the compound of chemical formula 4 to prepare a compound of chemical formula 5 a step of substituting the compound of chemical formula 5 to prepare a compound of chemical formula 6 a step of Suzuki coupling reaction of the compound of chemical formula 6 with a compound of chemical formula 7 to prepare a compound of chemical formula 8 a step of hydrogenation of the compound of chemical formula 8 to prepare a compound of chemical formula 9 a step of addition reaction of the compound of chemical formula 9 with a compound of chemical formula 10 to prepare a compound of chemical formula 11 and a step of deprotecting the compound of chemical formula 11.COPYRIGHT KIPO 2013본 발명은 하기 화학식 1로 표시되는 신규 다중치환 벤즈옥사졸로 치환된 피리딘 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 이상세포 성장 질환의 예방 및 치료용 약학적 조성물에 관한 것으로, 본 발명에 따르면 이상 세포 성장질환의 치료에 유용한 다양한 단백질 키나아제, 예를 들면 c-Met, Ron, KDR, Lck, Flt1, Flt3, Tie2, TrkA, TrkB, b-Raf, Aurora-A 등에 대하여 우수한 억제효과를 나타내므로, 이상 세포 성장 질환의 예방 및 치료에 유용하게 사용될 수 있다.[화학식 1](상기 화학식 1에서, R1~R4는 본 명세서에서 정의된 바와 같다.)
