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Spirocyclic cyclohexane derivatives
专利权人:
Grünenthal GmbH
发明人:
Hinze, Claudia,Aulenbacher, Otto,Sundermann, Bernd,Friderichs, Elmar,Englberger, Werner,Kögel, Babette-Yvonne,Linz, Klaus,Schick, Hans,Sonnenschein, Helmut,Henkel, Birgitta,Rose, Valerie Sarah,Lipkin,
申请号:
ES09009500
公开号:
ES2587013T3
申请日:
2003.11.05
申请国别(地区):
ES
年份:
2016
代理人:
摘要:
Spirocyclic cyclohexane derivatives of general formula I, ** Formula ** where R1 and R2 represent, independently of each other, H, CHO, branched or unbranched, saturated or unsaturated (C1-5) alkyl, unsubstituted; or the groups R1 and R2 together represent CH2CH2OCH2CH2, CH2CH2NR11CH2CH2 or (CH2) 3-6; R11 being equal to H; or (C1-5) alkyl, in each case saturated or unsaturated, branched or unbranched, unsubstituted; R3 represents (C1-5) alkyl, in each case saturated or unsaturated, branched or unbranched, substituted simply or multiple or unsubstituted; (hetero) C3-8 cycloalkyl, in each case saturated or unsaturated, substituted simply or multiple or unsubstituted; aryl, in each case substituted simply or multiplely or unsubstituted; or aryl or (hetero) C3-8 cycloalkyl, in each case substituted in a simple or multiple or unsubstituted form, linked through a (C1-3) alkyl, in each case saturated or unsaturated, branched or unbranched; W represents NR4, O or S; R4 being equal to H, saturated or unsaturated (C1-5) alkyl, branched or unbranched, substituted simply or multiple or unsubstituted; or substituted or unsubstituted aryl; R12 being equal to H, (C1-5) alkyl, in each case saturated or unsaturated, branched or unbranched, substituted simply or multiple or unsubstituted; (hetero) C3-8 cycloalkyl, in each case saturated or unsaturated, substituted simply or multiple or unsubstituted; aryl or heteroaryl, in each case substituted simply or multiplely or unsubstituted; or aryl, (hetero) C3-8 cycloalkyl or heteroaryl, in each case substituted in a simple or multiple or unsubstituted form, linked through a (C1-3) alkyl, in each case saturated or unsaturated, linear or branched ; OR13; or NR14R15; R5 represents (hetero) C3-8 cycloalkyl saturated or unsaturated, substituted simply or multiple or unsubstituted; aryl or heteroaryl substituted single or multiple or unsubstituted; or (hetero) C3-8 cycloalkyl or heteroaryl linked through a (C1-3) alkyl, in each case saturated or
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