A compound of general formula (I)；A is O, S, CH, NH or NR′, when O links with Z3, Z1 is N or CRZ1, Z2 is CRZ2, when Z1 links with O, Z2 is CH, Z3 is C—Ar； Ra, Rb, Rc and Rd independently is H, OH, halogen or —Y1—Rm； A1 is NH or CH2； R1′ is alkyl, aryl, cycloalkyl, heterocycloalkyl or heteroaryl； A2 is N, O or linking bond； R1 is hydrogen, or, R1 linking covalently with R3 forms C5-C9 saturated or unsaturated hydrocarbon chain substituted by O or N； R3 is alkyl, cycloalkyl, heterocycloalkyl, alkyl substituted by cycloalkyl etc； R4 is alkoxy-CO, alkyl-NHCO, (alkyl)2NCO, or formyl substituted by aryl, cycloalkyl, heterocycloalkyl.
