The object of present invention is to provide a substituted pyridine compound having excellent CETP inhibition activity and useful as a medicine, or pharmacologically acceptable salts thereof.The present invention provides a compound with general formula (I):[wherein, R1: H, optionally substituted alkyl, OH, optionally substituted alkoxy, alkylsulfonyl, optionally substituted amino, carboxy, optionally substituted carbonyl, CN, halo, optionally substituted phenyl, optionally substituted aromatic heterocyclyl, optionally substituted saturated heterocyclic group, optionally substituted saturated heterocyclyloxy, optionally substituted saturated heterocyclylcarbonyl and the like].本發明之課題係提供一種具有優異CETP抑制活性而有用於作為醫藥之經取代之吡啶化合物或其藥理上可容許的鹽。本發明提供一種具有通式(I)之化合物：[式中，R1：H、可經取代之烷基、OH、可經取代之烷氧基、烷基磺醯基、可經取代之胺基、羧基、可經取代之羰基、CN、鹵素基、可經取代之苯基、可經取代之芳香族雜環基、可經取代之飽和雜環基、可經取代之飽和雜環基氧基、可經取代之飽和雜環基羰基等]。
