Disclosed is a substituted pyridine compound that has excellent CETP inhibiting activity and is useful as a pharmaceutical or a pharmacologically acceptable salt thereof. Specifically disclosed is a compound etc. that fulfills a general formula (I) (wherein R: H substitutable alkyl OH optionally substituted alkoxy alkylsulfonyl optionally substituted amino carboxy optionally substituted carbonyl CN halogen optionally substituted phenyl optionally substituted aromatic heterocyclyl optionally substituted saturated heterocyclyl optionally substituted saturated heterocyclyloxy optionally substituted saturated heterocyclylcarbonyl etc.)
