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AZOLE DERIVATIVES
专利权人:
LTD.;TAJSO FARMASYUTIKAL KO.
发明人:
JOSINAGA Mitsukane (JP),ЙОСИНАГА Мицукане (JP),KUVADA Takesi (JP),КУВАДА Такеси (JP),MIYAKOSI Naoki (JP),МИЯКОСИ Наоки (JP),ISIZAKA Tomoko (JP),ИСИЗАКА Томоко (JP),VAKASUGI Dajsuke (JP),ВАКАСУГИ Дайсу,JOSINAGA Mitsukane,ЙОСИНАГА Мицукане,KUVADA Takesi,КУВАДА Такеси,MIYAKOSI Naoki,МИЯКОСИ Наоки,ISIZAKA Tomoko,ИСИЗАКА Томоко,VAKASUGI Dajsuke,ВАКАСУГИ Дайсуке,SIROKAVA Sin-iti,СИРОКАВА Син-ити,KHATTORI
申请号:
RU2014121205
公开号:
RU0002622639C2
申请日:
2012.10.25
申请国别(地区):
RU
年份:
2017
代理人:
摘要:
FIELD: pharmacology.SUBSTANCE: invention relates to azole derivative of formula (I) or its pharmaceutically acceptable salt, wherein R1 is hydrogen atom or C1-5alkyl; R2 is hydrogen atom or C1-5alkyl; R3 is phenyl or pyridyl (where phenyl or pyridyl is optionally substituted with one or two fragments selected from the group consisting of C1-5alkoxy, halogen and trifluoromethyl atoms); each of R4 and R5, which can be the same or different, represent hydrogen atom or C1-5alkyl (where C1-5alkyl is optionally substituted with one fragment selected from the group consisting of hydroxy and C1-5alkoxy), or R4 and R5 together with nitrogen atom joining them form 4-7-membered saturated or unsaturated heterocycle, optionally compirsing one cyclic nitrogen, oxygen or sulfur atom, aside from the mentioned above joining nitrogen atom (where 4-7-membered saturated and unsaturated heterocycle is optionally substituted with one or two fragments, selected from the group consisting of hydroxy C1-5alkyl (where C1-5 alkyl is optionally substitued with one or two hydroxyl group), C1-5alkoxy, halogen atoms, cyano, C2-5alkanoyl, aminocarbonyl, mono-C1-5alkylaminocarbonyl, di-C1-5 alkylaminocarbonyl, trifluoromethyl, amino, mono-C1-5alkylamino, di-C1-5alkylamino and C2-5alkylamino, wherein the mentioned 4-7-membered saturated or unsaturated heterocycle optionally has C1-5alkylene fragment, joining two different cyclic carbon atoms), or form 2-oxa-6-azaspiro[3.3]hept-6-yl or 7-oxa-2-azaspiro[3.5]non-2-yl; azole cycle represented by formula (α) has any structure of group (II) formula, contained in invention formula, and wherein Ry is hydrogen atom or C1-5alkyl; X1 and X2 are such that: (i) if X1 means an ordinary link or fragment -CO-, X2 means -C1-5alkylene- or -O-C1-5alkylene-; and (ii) if X1 means a fragment -CONRx1-, X2means an ordinary link; Rx1 is hydrogen atom or C1-5alkyl; and cycle A is benzol cycle, pyridine cycle (where benzol cycle is optionally substituted with one or two frag
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