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Substituted sulfonamide derivatives.
专利权人:
GRUENENTHAL GMBH
发明人:
MERLA, BEATRIX,OBERBOERSCH, STEFAN,REICH, MELANIE,SUNDERMANN, BERND,ENGLBERGER, WERNER,STRUENKER, TIMO,JOSTOCK, RUTH,HEES, SABINE,BIJSTERVELD, EDWARD,THEIL, FRITZ,GRAUBAUM, HEINZ
申请号:
ES08749188
公开号:
ES2376505T3
申请日:
2008.04.28
申请国别(地区):
ES
年份:
2012
代理人:
摘要:
Substituted sulfonamide derivatives of the general formula I, in which m represents 0, 1 or 2; n represents 0, 1 or 2; p represents 0, 1 or 2; q represents 0 or 1; A represents N, CH-NH-, CH-CH2NH-, CH-CH2-CH2-NH or CH-CH2-CH2-CH2-NH, and the individual H atoms may also be substituted by C1-5-alkyl; R 1 and R 2 mean, independently of each other, H; C1-6-alkyl, in each case saturated or unsaturated, branched or unbranched, substituted simply or multiple or unsubstituted; or aryl linked through a C1-3-alkyl chain, substituted simply or multiplely or unsubstituted, R 1 and R 2 not being equal to H at the same time; or the radicals R 1 and R 2 together mean CH2CH2OCH2CH2, CH2CH2NR 8 CH2CH2 or (CH2) 3-6; R 8 being equal to H; C1-6-alkyl, in each case saturated or unsaturated, branched or unbranched, substituted simply or multiple or unsubstituted; aryl, heteroaryl in each case substituted simply or multiplely or unsubstituted; or aryl or heteroaryl linked through a C1-3-alkyl chain, in each case substituted simply or multiple or unsubstituted; R 3 represents C1-8-alkyl, in each case saturated or unsaturated, branched or unbranched, substituted simply or multiple or unsubstituted; aryl or heteroaryl in each case substituted simply or multiplely or unsubstituted; or aryl or heteroaryl linked through a C1-3-alkyl chain, in each case substituted simply or multiple or unsubstituted; R 4 and R 4a represent, independently of each other, H; C1-6-alkyl, in each case saturated or unsaturated, branched or unbranched, substituted simply or multiple or unsubstituted; F; Cl; aryl, in each case substituted simply or multiplely or unsubstituted; or aryl linked through a C1-3-alkyl chain, in each case substituted simply or multiple or unsubstituted; R 5 and R 5a represent, independently of each other, H; C1-6-alkyl, in each case saturated or unsaturated, branched or unbranched, substituted simply or multiple or unsubstituted; OH, OC1-6-alkyl, F, Cl, phenoxy or benzyloxy; Q represents a s
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