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ПРОИЗВОДНЫЕ 2-ПИРИДИН-2-ИЛ-ПИРАЗОЛ-3(2H)-ОНА, ИХ ПОЛУЧЕНИЕ И ПРИМЕНЕНИЕ В ТЕРАПИИ
专利权人:
发明人:
Jean-Michel,Жан-Мишель,Valerie,Валери,Stephane,Стефан,Geraldine,Жеральдин
申请号:
EA201170900
公开号:
EA019774B1
申请日:
2009.12.24
申请国别(地区):
EA
年份:
2014
代理人:
摘要:
The invention relates to compounds with the formula (I), in a basic state or as an acid addition saltwhere n is equal to 0, 1, 2, 3 or 4 m is equal to 0, 1 or 2 o is equal to 0 or 1 X is a -CH2, -CH(R)-, -NH(R)- group or a heteroatom selected from among O and S, where R is a -(C1-C5)alkyl, -(C1-C5)alcoxy, -CH2-phenyl, -C(O)R5 or -COOR5 group, wherein R5 is as defined herein R1 is an oxo or -COOR5 group, wherein R5 is as defined herein R2 is an H atom or a group selected from among the following groups: -(C1-C5)alkyl, -(C1-C5)alcoxy, -COOR5, -NR5R6, -C(O)NR5R6, -SO2-NR3R4, heteroaryl optionally substituted by a -(C1-C5)alkyl group, -W-phenyl, -W-heteroaryl, -O-W-phenyl and -O-W-heteroaryl, where W, R3, R4, R5 and R6 are as defined herein, provided that R3 and R4, which may be identical or different, (i) independently from one another are an H atom, a -(C1-C5)alkyl, -(C3-C6)cycloalkyl, phenyl, heteroaryl, -CH2-heteroaryl or -W-OH or (ii) together with the nitrogen atom that carries them, jointly form a heterocycloalkyl group, optionally substituted by one or more groups selected from among the -(C1-C5)alkyl and -CH2-phenyl groups W is a -(C1-C5)alkylene group, optionally substituted by one or more hydroxy groups R5 and R6, which may be identical or different, independently from one another are a hydrogen atom or groups selected among the -(C1-C5)alkyl groups and the -(C3-C6)cycloalkyl groups, wherein heteroaryl is selected from furanyl, oxadiazolyl and pyridinyl heterocycloalkyl is selected from 5-, 6- or 7-membered saturated cycle containing a nitrogen atom and also to the preparation method and to the therapeutic uses of said compounds.Изобретение относится к соединениям, соответствующим формуле (I), в виде основания или кислотно-аддитивной солигде n равно 0, 1, 2, 3 или 4 m равно 0, 1 или 2 о равно 0 или 1 X представляет собой -СН2, -CH(R)-, -N(R)- или гетероатом, выбранный из атома кислорода и атома серы, при условии, что R представляет собой -(С1-С5)алкил, -(С1-С
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