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Tetrahydro-tetrazolo [1,5-a] pyrazines as ROR-gamma inhibitors
专利权人:
Merck Patent GmbH
发明人:
FINSINGER, Dirk,WUCHERER-PLIETKER, Margarita,BLUME, Beatrix
申请号:
ES14806178
公开号:
ES2663498T3
申请日:
2014.11.26
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
Compound of formula (I) ** (See formula) ** where R1 indicates -R3, -CH2-R3 or - (C>; = O) -R3; R2 indicates Ar2, Hetar2 or C3-7 cycloalkyl; R3 indicates Ar3, Hetar3 or C3-7 cycloalkyl; Ar2 and Ar3 independently indicate each other a mono or bicyclic aromatic hydrocarbon system with 6 to 10 carbon atoms whose system is not substituted or is substituted with one or more identical or different substituents selected from the group consisting of C1-6 alkyl, C 1-6 alkoxy, C 3-7 cycloalkyl, -NH 2, N- (C 1-6 alkyl) amino, N, N- (di-C 1-6 alkyl) amino, halogen, -C 1-3 alkyl- OR-; Hetar2 indicates a mono or bicyclic aromatic heterocycle of 4, 5, 6, 7, 8, 9 or 10 atoms with 1, 2 or 3 atoms of N and / or O and / or S, whose heterocycle is unsubstituted or substituted with one or more identical or different substituents selected from the group consisting of C1-6 alkyl, C3-7 cycloalkyl, (C1-6 alkyl) m-aryl, where m is 0 or 1 and aryl is a hydrocarbon system mono or bicyclic aromatic with 6 to 10 carbon atoms whose aromatic hydrocarbon system is not substituted or is substituted by one or more identical or different substituents selected from the group consisting of C1-6 alkyl, C1-6 alkoxy, cycloalkyl- C3-7, -NH2, N- (C1-6 alkyl) amino, N, N- (di-C1-6 alkyl) amino, halogen; Hetar3 indicates a mono or bicyclic aromatic heterocycle of 4, 5, 6, 7, 8, 9 or 10 atoms with 1, 2 or 3 atoms of N and / or O and / or S, whose system is not substituted or substituted with one or more identical or different substituents selected from the group consisting of C1-6 alkyl, C3-7 cycloalkyl, (C1-6 alkyl) n-aryl where n is 0 or 1 and aryl is an aromatic hydrocarbon system mono or bicyclic with 6 to 10 carbon atoms whose aromatic hydrocarbon system is not substituted or is substituted by one or more identical or different substituents selected from the group consisting of C1-6 alkyl, C1-6 alkoxy, C3 cycloalkyl -7, -NH2, N- (C1-6 alkyl) amino, N, N- (di-C1-6 alkyl) amino, halogen; or solvates, tauto
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