A thioxanthone ring system derivative compound is provided. The thioxanthone ring system derivative compound is represented by a formula (I): wherein X is a substituent being one selected from a group consisting of halogens, wherein R1 is a substituent being one selected from a group consisting of sulfur and sulfur dioxide, wherein R2 is a substituent being one selected from a group consisting of C1~C10 alkyl group, C3~C10 branched alkyl group, C3~C10 cyclic alkyl group, phenyl group, phenyl alkyl group. Wherein phenyl hydrogen is a substituent being one selected from a group consisting of halogens, alkoxyl group, C1~C10 alkyl group, nitro group, amine group.本發明提供一系列噻噸酮衍生物,並進一步提供該些衍生物之製備方法及包含上述噻噸酮衍生物之醫藥組合物。上述噻噸酮衍生物係由式I所示式I中,X代表鹵系元素,R1代表S或SO2,R2係可選自由C1-10直鏈烷基、C3-10支鏈烷基、C3-10環狀烷基、苯基以及苯基烷基所組成之群組,且苯基的氫元素可部分地由鹵系元素、烷氧基、C1-10烷基、硝基或胺基取代。