KIM, Hong Woo,KOH, Jong Sung,LEE, Jaekyoo,SONG, Ho-Juhn,KIM, Youngsam,LEE, Hee Kyu,CHOI, Jang-Sik,LIM, Sun-Hee,CHANG, Sunhwa
申请号：
ES10827573
公开号：
ES2658290T3
申请日:
2010.10.29
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of Formula (I): ** (See formula) ** in which: R1 is H, X is NR2R3 or NR4R5 Y is NHR6 and Z is selected from H, halogen or C1-C3 alkyl； wherein: R2 and R3, taken together with the nitrogen atom to which they are linked form: i) a 3-8 membered saturated or partially saturated monocyclic group that does not have any heteroatom other than the nitrogen atom to which R2 is linked and R3, wherein said 3-8 membered saturated or partially saturated monocyclic group is independently substituted at one or more carbon atoms with 1-2 R7 and optionally substituted at one or more carbon atoms with 0-4 R8, in which R7 is hydroxy, heterocycloalkyl or NR9R9 and R8 is hydroxyalkyl (C1-C6), aryl, COOR9, (CH2) nNR9R9, or (CH2) nNR9R10, in which each n is independently 1, 2 or 3 and the aryl is optionally substituted with halo； or ii) an 8-10 membered bicyclic aryl group having 0-5 heteroatoms independently selected from nitrogen, oxygen, sulfur, sulfoxide or sulfone； each R9 is independently selected from H, C1-C6 alkyl, C3-C6 alkynyl, C2-C6-cyano alkyl, C2-C6-sulfone alkyl, C3-C6-sulfone cycloalkyl, C2-C6 sulfonamide, C3-C6 cycloalkyl, heterocycloalkyl C3-C8, aryl, aryl (C1-C6) alkyl or heteroaryl, in which alkyl, alkynyl, alkylcyanol, alkylsulfone, sulfonamide, cycloalkyl, heterocycloalkyl, aryl, arylalkyl or heteroaryl is optionally substituted with R25； R10 is C (O) R9, COOR9, C (O) NR9R9, or S (O) nR9, where n is 1 or 2； R4 is selected from H, C1-C6 alkyl or hydroxy (C1-C6) alkyl； R5 is aryl (C1-C3) alkyl, in which the aryl group is independently substituted at one or more carbon atoms with 1-3 R11, in which R11 is independently selected from OR9, NR9R9, NR9COR9, or NR9S (O) nR9, in which n is 1 or 2； R6 is aryl, and wherein the aryl is substituted on one or more carbon atoms with CF3, wherein the aryl of R6 is independently selected from: i) a 5-6 membered monocyclic aryl group； ii) an 8-10 membered bicyclic aryl group having 0-5 heteroatoms independently selected from
