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Pyrrolopyrimidine derivative
专利权人:
Ltd.;ONO Pharmaceutical Co.
发明人:
INUKAI, Takayuki,TAKEUCHI, Jun,YASUHIRO, Tomoko,WOLF, Mark Allan,PAWAR, Vijay Dattaram,CHAKRABARTI, Anjan,CHITTIMALLA, Santhosh Kumar
申请号:
ES14859491
公开号:
ES2685661T3
申请日:
2014.11.06
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
A compound represented by the general formula (1): ** Formula ** wherein R1 represents (1) a C1-8 alkyl group optionally substituted with one to five R11, (2) an optionally substituted C3-7 carbon ring with one to five R12, or (3) a 4- to 7-membered heterocycle optionally substituted with one to five R13, wherein, when the C1-8 alkyl group represented by R1 is a branched alkyl group, the C1 alkyl groups -3 branched from the same carbon atom together optionally form a saturated C3-7 carbon ring, R2 represents (1) a C1-8 alkyl group optionally substituted with one to five R21, (2) a C2- alkenyl group 8 optionally substituted with one to five R22, (3) a C2-8 alkynyl group optionally substituted with one to five R23, (4) a -OR24 group, (5) a C3-7 carbocyclic ring optionally substituted with one to five R25, (6) 4- to 7-membered heterocycle optionally substituted with one to five R26, (7) a halogen atom, (8) a C (O) R27 group or (9) a C (O) NR28R29 group, where, when m is 2 or more, R2 are in neighboring carbon atoms, and each R2 represents a C1-3 alkyl group optionally substituted with an amino group or with a C2-3 alkenyl group optionally substituted with an amino group, when R2 attached to neighboring carbon atoms together with carbon atoms can form a cyclic group of 5 to 7 members optionally substituted with one to three R20, R3 represents (1) a C1-4 alkyl group, (2) a halogen atom, (3) a C1-4 haloalkyl group or (4) a group - OR31, R4 represents (1) a hydrogen atom, (2) a C1-8 alkyl group optionally substituted with one to five R41, (3) a C3-10 carbocyclic ring optionally substituted with one to five R42, or (4) a heterocycle 4 to 4 members optionally substituted with one to five R43, R5 represents (1) a hydrogen atom, (2) a C1-4 alkyl group, (3) a halogen atom or ( 4) a C1-4 haloalkyl group, R11 represents (1) a group -OR101, (2) a group SO2R102, (3) a group NR103R104 or (4) a C3-7 carbon ring optionally substituted with one to three halogen atoms, R12 represents (1
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