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Carbamate / urea derivatives containing piperidine and piperazine rings as H3 receptor inhibitors.
专利权人:
Novartis AG
发明人:
WANG, Tielin,ZHANG, Xuechun
申请号:
ES12795066
公开号:
ES2624421T3
申请日:
2012.10.08
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound of the formula I: ** Formula ** or a salt thereof, wherein: R 1 is alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, cycloalkenyl of 5 to 6 carbon atoms or cycloalkyl of 3 to 6 carbon atoms-alkyl of 1 to 4 carbon atoms; wherein this alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms or cycloalkyl of 3 to 6 carbon atoms-alkyl of 1 to 4 carbon atoms may be substituted once or more than once by halogen, hydroxyl, or alkoxy of 1 to 4 carbon atoms; and wherein the cycloalkyl of 3 to 6 carbon atoms or cycloalkenyl of 5 to 6 carbon atoms may be substituted once or more than once by halogen, hydroxyl, alkyl of 1 to 4 carbon atoms, halo-alkyl of 1 at 4 carbon atoms, hydroxyalkyl of 1 to 4 carbon atoms or alkoxy of 1 to 4 carbon atoms; m is 1 or 2; n is 0, 1, 2, 3 or 4; each R2 is independently halogen, hydroxyl, amino, cyano, nitro, alkyl of 1 to 6 carbon atoms, halo-alkyl of 1 to 6 carbon atoms, hydroxy-alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 4 carbon-alkyl atoms of 1 to 6 carbon atoms, amino-alkyl of 1 to 6 carbon atoms, alkyl of 1 to 4 carbon atoms-amino-alkyl of 1 to 6 carbon atoms, di- (alkyl of 1 at 4 carbon atoms) -amino alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, halo-alkoxy of 1 to 6 carbon atoms, alkyl of 1 to 6 carbon atoms-amino, di- (alkyl of 1 to 6 carbon atoms) -amino, alkenyl of 2 to 6 carbon atoms, halo-alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms or halo-alkynyl of 2 to 6 atoms carbon; or cycloalkyl of 3 to 6 carbon atoms, wherein a carbon atom can be replaced by an oxygen atom, wherein the cycloalkyl of 3 to 6 carbon atoms can be attached directly to methylene or by means of an alkylene of 1 at 2 carbon atoms, and wherein the cycloalkyl of 3 to 6 carbon atoms may be substituted once or more than once by halogen; or two R2 in the same carbon atom together with that carbon atom, a cycloalk
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