БАРР Кеннет Джей (US),БЕЙНСТОК Кори (US),МАКЛИН Джон (US),ЧЖАН Хунцзюнь (US),БЕРЕЗИС Ричард Томас (CN),ЧЖАН Дуншань (CN),ЭНТОНИ Невилл (US),ЛАПОЙНТ Блэйр (US),ТЯНЬ Юань (US)
申请号：
RU2015108894
公开号：
RU2015108894A
申请日:
2013.08.14
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. The compound according to formula I: or a pharmaceutically acceptable salt or solvate thereof, wherein: Y is CH, CR or N； N is 0, 1, 2, 3 or 4； A is CR or N, A is CR or N, A is CR or N, A is CR or N, provided that no more than two of the A-A can be N； R is (C) alkyl or (C) cycloalkyl； R is: (i) (C) carbocyclyl (C) alkyl； (ii) a 4-12 membered heterocyclyl (C) alkyl or (iii) (C) alkoxy, each optionally substituted with one, two, three, four or five R； R is a guide roxycarbonyl, hydroxycarbonyl (C) alkyl, (C) alkylsulfoxyaminocarbonyl or carbamoyl； R is hydrogen, halogen, cyano, nitro, hydroxy, (C) alkylcarbonyloxy, (C) alkylsulfonylamino, (C) alkylcarbonylamino, (C) alkylamino, alkyl, hydroxyl (C) alkyl or (C) alkoxy, where (C) alkyl and (C) alkoxy are optionally substituted with one or more halogens； R-R are independently hydrogen, halogen, amino, cyano, hydroxy, (C) alkoxy, (C) alkyl, (C) alkylaminocarbonyl, (C) alkyloxycarbonylamino, (di) (C) alkylaminocarbonyl, (C) alkylcarbonylamino, (C) alkylamino, and mino (C) alkyl or formaldehyde, where (C) alkoxy, (C) alkyl, (C) alkyl) aminocarbonyl, (di) (C) alkylaminocarbonyl, (C) alkylamino and amino (C) alkyl are optionally substituted with one or more halogens , hydroxyl or (C) alkoxy； or a group of the formula optionally substituted by one or more of the following: (C) alkyl, halogen, amino, cyano, hydroxy, (C) alkoxy, and where m is 1, 2, 3 or 4； R is: (i) (C) ) cycloalkyl or (C) heterocycloalkyl, both optionally substituted with one or more groups selected from halogen, amino, amino (C) alkyl, cyano, nitro, hydroxyl, oxo (= O), HNC (O), (C) alkoxycarbonyl, (di) (C) alkylaminocarbonyl, (C) alkyl or (C) alkoxy, where (C) alkoxycarbonyl,1. Соединение, соответствующее формуле I:или его фармацевтически приемлемая соль или сольват, где:Y представляет собой CH, CRили N；N равно 0, 1, 2, 3 или 4；Aпредставляет собой CRили N,Aпредставляет собой CRили N,Aпредставляет собой CRили N,Aпредставляет собой CRили N,при условии, что
