The present invention is related to the compounds of formula shown as following, pharmaceutically acceptable salts or solvates thereof.(wherein, X is =CR4- or =N- Y is =CR5- or =N- Z is =CR7- or =N- R4 and R7 each independently are hydrogen, halogen, cyano, substituted or non-substituted alkyl etc. when X is =CR4-, Y is =CR5-, and Z is =CR7-, R4 and R7 are not hydrogen simultaneously when X is =CR4-, Z is =CR7-, and R4 is halogen, R7 is not hydrogen R5 and R6 each independently are hydrogen, halogen, hydroxyl, cyano, nitro, carboxyl, substituted or non-substituted alkyl etc. R1 and R2 each independently are hydrogen, halogen, hydroxyl, cyano, nitro, carboxyl, substituted or non-substituted alkyl etc. R3 is a group shown as formula: -(CR8R9)m-R10 R8 independently is hydrogen, halogen, hydroxyl etc. R9 independently is hydrogen, halogen, hydroxyl etc. m is 0 to 3 R10 is carboxyl, substituted or non-substituted alkoxycarbonyl etc.).本發明為一種下式所示之化合物、其製藥上可接受之鹽或彼等之溶劑合物(式中,X為=CR4-或=N-;Y為-CR5=或-N=;Z為=CR7-或=N-;R4及R7為各自獨立之氫、鹵素、氰基、經取代或未經取代之烷基等;當X為=CR4-、Y為-CR5=、且Z為=CR7-時,R4及R7不同時為氫;當X為=CR4-、Z為=CR7-、且R4為鹵素時,R7不為氫;R5及R6為各自獨立之氫、鹵素、羥基、氰基、硝基、羧基、經取代或未經取代之烷基等;R1及R2為各自獨立之氫、鹵素、羥基、氰基、硝基、羧基、經取代或未經取代之烷基等;R3為式:-(CR8R9)m-R10所示之基;R8為各自獨立之氫、鹵素、羥基等;R9為各自獨立之氫、鹵素、羥基等;m為0~3之整数;R10為羧基、經取代或未經取代之烷氧羰基等)。
