The present invention is concerned with 2-oxo-2,3-dihydro-indoles of general formulawherein Ar is a heteroaryl group, containing one, two or three heteroatoms, selected from N, S or O R1is hydrogen, lower alkyl, halogen, amino, dimethylamino, cyano, lower alkyl substituted by halogen, lower alkyl substituted by hydroxy, CH(OH)CF3, (CH2)o-lower alkoxy, cycloalkyl optionally substituted by CF3, or heterocycloalkyl optionally substituted by lower alkyl R2is hydrogen, lower alkyl, (CH2)o-cycloalkyl, (CH2)o-O-cycloalkyl, (CH2)o-lower alkoxy, CH2)o-lower alkoxy substituted by halogen, (CH2)o-heterocycloalkyl optionally substituted by lower alkyl, (CH2)o-S(O)2-cycloalkyl, lower alkyl substituted by one or two hydroxy, lower alkyl substituted by one or two lower alkoxy, (CH2)o-S(O)2-lower alkyl, lower alkyl substituted by halogen or CH2CH(OH)CF3 R3is halogen or lower alkyl X is CH or N X1is CH or N n is 1 or 2 o is 0, 1, 2 or 3 m is 0, 1 or 2 and the dotted line is a bond or not as well as with a pharmaceutically acceptable salts thereof, with a racemic mixture, or with its corresponding enantiomer and/or optical isomer and/or stereoisomer thereofThe compounds may be used for the treatment of certain central nervous system disorders which are positive (psychosis) and negative symptoms of schizophrenia, substance abuse, alcohol and drug addiction, obsessive-compulsive disorders, cognitive impairment, bipolar disorders, mood disorders, major depression, treatment resistant depression, anxiety disorders, Alzheimer’s disease, autism, Parkinson’s disease, chronic pain, borderline personality disorder, sleep disturbances, chronic fatigue syndrome, stiffness, antiinflammatory effects in arthritis and balance problems.本發明係關於以下通式之2-側氧基-2,3-二氫-吲哚其中Ar 係含有1個、2個或3個選自N、S或O之雜原子之雜芳基;R1係氫、低碳烷基、鹵素、胺基、二甲基胺基、氰基、經鹵素取代之低碳烷基、經羥基取代之低碳烷基、CH(OH)CF3、(CH2)o-低碳烷氧基、視情況經CF3取代之環烷基或視情況經低碳烷基取代之雜環烷基;R2係氫、低碳烷基、(CH2)o-環烷基、(CH2)o-O-環烷基、(CH2)o-低碳烷氧基、經鹵素取代之(CH2)o-低碳烷氧基、視情況經低碳烷基取代之(CH2)o-雜環烷基、(CH2)o-S(O)2-環烷基、經一或兩
