A compound of formula (II) wherein represents a divalent benzene residue which is unsubstituted or substituted by one or two additional substituents independently selected from lower alkyl, halo-lower alkyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl, acyloxy-lower alkyl, phenyl, hydroxy, lower alkoxy, hydroxy-lower alkoxy, lower alkoxy-lower alkoxy, phenyl-lower alkoxy, lower alkylcarbonyloxy, amino, mono(lower alkyl)amino, di(lower alkyl)amino, mono(lower alkenyl)amino, di(lower alkenyl)amino, lower alkoxycarbonylamino, lower alkylcarbonylamino, substituted amino wherein the two substituents on nitrogen form together with the nitrogen heterocyclyl, lower alkylcarbonyl, carboxy, lower alkoxycarbonyl, cyano, halogen, and nitro； or wherein two adjacent substituents can be methylenedioxy； or a divalent pyridine residue (Z = N) which is unsubstituted or substituted additionally by lower alkyl, lower alkoxy, lower alkoxy-lower alkoxy, amino, optionally substituted by one or two substituents selected from lower alkyl, lower alkenyl and alkylcarbonyl, halo-lower alkyl, lower alkoxy-lower alkyl, or halogen； R1 represents hydrogen, lower alkylcarbonyl, hydroxy-lower alkyl or cyano-lower alkyl； and R2 represents a group selected from: , , and ； or pharmaceutically acceptable salts thereof.本發明係關於一種式(II)化合物其中表示二價苯殘基，其未經取代或經一或兩個獨立地選自以下之其他取代基取代：低碳烷基、鹵基-低碳烷基、羥基-低碳烷基、低碳烷氧基-低碳烷基、醯氧基-低碳烷基、苯基、羥基、低碳烷氧基、羥基-低碳烷氧基、低碳烷氧基-低碳烷氧基、苯基-低碳烷氧基、低碳烷基羰氧基、胺基、單(低碳烷基)胺基、二(低碳烷基)胺基、單(低碳烯基)胺基、二(低碳烯基)胺基、低碳烷氧基羰基胺基、低碳烷基羰基胺基、經取代之胺基(其中氮上之兩個取代基與氮一起形成雜環基)、低碳烷基羰基、羧基、低碳烷氧基羰基、氰基、鹵素及硝基；或其中兩個相鄰取代基可為亞甲二氧基；或二價吡啶殘基(Z=N)，其未經取代或另外經以下取代：低碳烷基、低碳烷氧基、低碳烷氧基-低碳烷氧基、胺基(其視情況經一或兩個選自低碳烷基、低碳烯基及烷基羰基之取代基取代)、鹵基-低碳烷基、低碳烷氧基-低碳烷基或鹵素；R1表示氫、低碳烷基羰基、羥基-低碳烷基或氰基-低碳烷基；及R2表示選自以下之基團：或其醫藥學上可接受之鹽。
