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PHENYLIMIDAZOLE COMPOUND
专利权人:
OTSUKA PHARMACEUTICAL FACTORY; INC.
发明人:
SHIBUTANI, TADAO,澁谷直应,澁谷直應,IWATA, KOUSHI,岩田效志,岩田效志,KIDO, SATOSHI,木户智史,木戶智史
申请号:
TW099103198
公开号:
TWI435871B
申请日:
2010.02.03
申请国别(地区):
TW
年份:
2014
代理人:
摘要:
To provide a pharmaceutical product (chemotherapeutic agent) effective in the prevention and treatment of hyperlipidemia, obesity, etc.A phenylimidazole compound represented by the following General Formula (1):wherein, R1represents a hydrogen atom, a phenyl lower alkyl group optionally having a substituent, or a pyridyl lower alkyl group optionally having a substituent, and the benzene ring and the pyridine ring are optionally substituted with 1 or 2 substituents selected from the group consisting of halogen atoms, cyano group and halogen-substituted lower alkyl groups. One of R2and R3represents a hydrogen atom and the other represents a lower alkoxy group. R4represents a phenyl group optionally having a substituent. R5and R6are the same or different, and represent a hydrogen atom or a lower alkyl group. R7and R8are the same or different, and represent a hydrogen atom or a lower alkoxy group. However, when R1represents an unsubstituted phenyl lower alkyl group, R2represents a lower alkoxy group, R3represents a hydrogen atom, R4represents a phenyl group optionally having a substituent, and R5represents a hydrogen atom, R6is not a hydrogen atom.為了提供在高脂血症、肥胖症等之預防及治療上有效的醫藥品(化學療劑)。由下述通式(1)代表之苯基咪唑化合物:[式中R1表示氫原子、苯基低級烷基或吡啶基低級烷基,且苯環及吡啶環任擇地具有1或2個選自於鹵素原子、氰基及經鹵素取代之低級烷基的基團作為取代基。R2及R3中一者表示氫原子且另一者表示低級烷氧基。R4表示低級烷基、呋喃基、噻吩基,或具有1或2個選自於低級烷基、低級烷氧基、鹵素原子、羧基、低級烷氧基羰基及經鹵素取代之低級烷基的基團作為取代基的苯基。R5及R6為相同或不同,且表示氫原子或低級烷基。R7及R8為相同或不同,且表示氫原子或低級烷氧基。然而,當R1表示未經取代的苯基低級烷基、R2表示低級烷氧基、R3表示氫原子、R4表示未經取代的苯基或具有1或2個經鹵素取代之低級烷基的苯基,且R5表示氫原子時,R6不得為氫原子]。
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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