LIN, NAN HORNG,林南宏,林南宏,KUO, MANN YAN,郭曼娫,郭曼娫,LIAO, CHU BIN,廖助彬,廖助彬,PENG, SHAO ZHENG,彭劭政,彭劭政,YEN, SHIH CHIEH,严士杰,嚴士傑
申请号：
TW102147152
公开号：
TWI624461B
申请日:
2013.12.19
申请国别(地区):
TW
年份:
2018
代理人:
摘要：
A compound for treating a protein kinase-related disease or disorder having a structure of formula (I) or alkyne X is N or CH L1 is N(R7)-, -O-, -C(S)-, -C(O)-, or -S- L2 is -N(R8)- or -O- R1 and R2 are independently hydrogen, halogen, hydroxyl, amino, cyano, nitro, carboxy, C1-C4 alkoxy, C1-C4 alkoxy C1-C4 alkoxy, N,N-(C1-C4 dialkyl)amino C1-C4 alkoxy, N-(C1-C4 alkyl)amino C1-C4 alkoxy, C1-C4 alkanoyl, C1-C4 alkanoyloxy, N-(C1-C4 alkyl)amino, N,N-(C1-C4 dialkyl)amino, C1-C4 alkanoyl amino, or heterocyclyl, wherein C1-C4 alkyl is optionally substituted with one or more substituents selected from fluorine and chlorine R3, R4 and R5 are independently hydrogen, fluorine or chlorine R6 is C1-C4 alkyl or aryl, which is optionally substituted with one or more substituents selected from halogen, hydroxyl, amino, cyano, nitro or R6 and R8 form a 5-6 membered cyclyl or heterocyclyl.一種用於治療蛋白激酶相關疾病之化合物,其具有式(I)之結構:其中G為雜芳基、雜環基或炔基;X為N或CH;L1為-N(R7)-、-O-、-C(S)-、-C(O)-或-S-;L2為-N(R8)-或-O-;R1與R2各別為氫、鹵素、羥基、胺基、氰基、硝基、羧基、C1-C4烷氧基、C1-C4烷氧基C1-C4烷氧基、N,N-(C1-C4二烷基)胺基C1-C4烷氧基、N-(C1-C4烷基)胺基C1-C4烷氧基、C1-C4烷醯基、C1-C4烷醯氧基、N-(C1-C4烷基)胺基、N,N-(C1-C4二烷基)胺基、C1-C4烷醯基或雜環基;其中,C1-C4烷基可視需要由一或多個選自氟和氯之取代基取代;R3、R4和R5各別為氫、氟或氯;R6為C1-C4烷基或芳香基,其可視需要經一個或多個選自鹵素、羥基、胺基、氰基與硝基之取代基取代;或R6與R8為選自於5-6員環基或雜環基。
