FUJIAN INSTITUTE OF RESEARCH ON THE STRUCTURE OF MATTER; CHINESE ACADEMY OF SCIENCES
发明人:
LU, Canzhong,卢灿忠,YONG, Jianping,雍建平
申请号：
CNCN2012/086251
公开号：
WO2013/143319A1
申请日:
2012.12.10
申请国别(地区):
WO
年份:
2013
代理人:
摘要：
The present invention provides a quinazoline compound shown in formula (I), or pharmaceutically acceptable salt thereof. R1, R2 and R7 are independently and respectively selected from hydrogen, C1-6 alkyl, C1-6 alkoxy, halogenate C1-6 alkyl, halogenate C1-6 alkoxy, hydroxyl C1-6 alkyl, hydroxyl C1-6 alkoxy, C1-6 alkoxy C1-6 alkoxy, C3-8 cycloalkyloxy, optional aryl or heteroaryl substituted by R6, nitryl, amino, C1-6 alkylamino, and di(C1-6 alkyl)amino it comprises at least one C3-8 heterocycloalkyloxy selected from N, O, S heteroatoms Z is -NR4-, C(R5)2, S or -O-, R4 being hydrogen or C1-3 alkyl, and R5 being selected from hydrogen or C1-3 alkyl R3 is selected from hydrogen, halogen, C1-6 alkyl, C1-6 alkoxy or halogenate C1-6 alkyl R6 is selected from hydrogen, C1-3 alkyl, hydroxyl, halogen, C1-3 alkoxy and n is 0 to 5. The present invention further provides a preparation method of the compound shown in formula (I) or the pharmaceutically acceptable salt and pharmaceutical usage thereof, which can be used as medicines or lead compounds for curing diseases such as tumour and cancer related to protein tyrosine kinase.La présente invention concerne un composé de quinazoline représenté dans la formule (I), ou sel pharmaceutiquement acceptable de celui-ci. R1, R2 et R7 sont sélectionnés indépendamment et respectivement à partir dhydrogène,C1-6 alkyl, C1-6 alkoxy, halogenate C1-6 alkyl, halogenate C1-6 alkoxy, hydroxyl C1-6 alkyl, hydroxyl C1-6 alkoxy, C1-6 alkoxy C1-6 alkoxy, C3-8 cycloalkyloxy, aryle éventuel ou hétéroaryle substitué par R6, nitryl, amino, C1-6 alkylamino, et di (C1-6 alkyl)amino il comprend au moins un C3 -8 hétérocycloalkyloxy sélectionné à partir de N, O, S hétéroatomes Z est-NR4-, C (R5) 2, S ou-O-, R4 étant lhydrogène ou Cl -3 alkyl, et R5 étant choisi parmi de lhydrogène ou Cl -3 alkyle R3 est choisi à partir dhydrogène, halogène, Cl -6 alkyle, Cl -6 alcoxy ou dhalogénation de Cl -6 alkyle R6 est choisi à partir dhydrogène, Cl -3 alkyle, hydr
