A compound of formula (I) ** Formula ** its N-oxide forms, its pharmaceutically acceptable addition salts and its stereochemically isomeric forms, in which: R 1 is hydroxyl or a radical of the formula (a-1) ** Formula ** in which: R2 is hydroxyl or amino； R3 is hydrogen, thienyl, furanyl or phenyl and each thienyl, furanyl or phenyl may be optionally substituted with one or two halo, amino, nitro, cyano, hydroxyl, phenyl, C1-6 alkyl, (C1-6 dialkyl) amino, alkyl C1-6-oxy, phenyl-C1-6-oxy alkyl, hydroxy C1-6 alkyl, alkoxy C1-6-carbonyl, hydroxycarbonyl, C1-6 alkylcarbonyl, polyhaloalkyl C1-6-oxy, polyhaloalkyl C1-6, alkyl C1-6-sulfonyl, hydroxycarbonylalkyl C1-6, alkyl C1-6-carbonylamino, aminosulfonyl, aminosulfonylalkyl C1-6, isoxazolyl, aminocarbonyl, phenylalkyl C2-6, phenylalkyl C3-6 or pyridinylalkyl C3-6； R4, R5 and R6 are each independently, amino, nitro, furanyl, halo, C1-6 alkyl, C1-6-oxy alkyl, trifluoromethyl, thienyl, phenyl, C1-6 alkylcarbonylamino, C1-6 aminocarbonylalkyl or -CC -CH2-R7； wherein R 7 is hydrogen, C 1-6 alkyl, hydroxy, amino or C 1-6 alkyl-oxy； X is N or CH； Y is O, N, NH, CH or CH2 and when Y is N or CH then the substituent is attached to the Y atom of the ring structure； T is O or NR8 in which R8 is hydrogen, C1-6 alkyl, C3-7 cycloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, C1-6 alkyl C1-6 oxyalkyl, C1-6 hydroxyaminocarbonylalkyl, C1 alkyl -6-sulfonylC 1-6 alkylcarbonyl, C 1-6 alkylcarbonyl or mono- or di- (C 1-6 alkyl) aminosulfonyl； n is 0 or 1 and when n is 0 it means a direct link； m is 1 or 2； p is 0 or 1 provided that when p is 0 then n is 0, - (CH2) n- (T) p- is a direct link and Y is N； A is a radical selected from: ** Formula ** in which R9 is hydrogen, C1-6 alkyl, C3-7 cycloalkyl or C3-7 cycloalkyl-C1-6 alkyl； and R 10 is hydrogen, hydroxy, amino, halo, C 1-6 alkyl, C 1-6 polyhaloalkyl, C 1-6 alkyl oxycarbonyl, hydroxycarbonyl, C 1-6 alkylcarbonylamino, C 1-6 alkyl oxy, or mono- or di - (C1-6 alkyl) amino.Un compuesto de fórmul
