MABIRE, Dominique Jean-Pierre,VAN DUN, Jacobus,SOMERS, Maria,WOUTERS, Walter Boudewijn Leopold
申请号：
ES04803192
公开号：
ES2565581T3
申请日:
2004.11.18
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of formula (I), ** Formula ** an N-oxide form, an addition salt or a stereochemically isomeric form thereof, in which n is 0 or 1； s is 0 or 1； X is -N>； = or -CR4>； =, where R4 is hydrogen or taken together with R1 can form a bivalent radical of the formula -CH>； = CH-CH>； = CH-； Y is -N <；or -CH <；； Q is -NH-, -O-, -C (O) -, -CH2-CH2- or -CHR5-, wherein R5 is hydrogen, hydroxy, C1-6 alkyl, aryl-C1-6 alkyl, C 1-6 alkyl-oxycarbonyl, C 1-6 alkyl-oxy-C 1-6 alkyl or haloindazolyl； R1 is C1-6 alkyl or thienyl； R2 is hydrogen； R3 is hydrogen, C1-6 alkyl or a radical selected from -NR6R7 (a-1), -OH (a-2), -O-R8 (a-3), -S-R9 (a-4), or -C≡N (a-5), in which R6 is -CHO, C1-6 alkyl, hydroxy-C1-6 alkyl, C1-6 alkylcarbonyl, di (C1-6 alkyl) amino-alkyl C1-6, C1-6 alkyl-carbonylamino-C1-6 alkyl, piperidinyl-C1-6 alkyl, piperidinyl-C1-6-alkylcarbonyl, C1-6-oxy alkyl, C1-6-oxy alkyl C 1-6, C 1-6 thienyl alkyl, C 1-6 pyrrolyl alkyl, C 1-6 aryl-alkyl-piperidinyl, C 1-6 arylcarbonylalkyl, C 1-6 arylcarbonylpiperidinylalkyl, C 1-6 haloindazolylpiperidinylalkyl, or C 1-6 arylalkyl (C1-6 alkyl) C1-6 amino-alkyl； and R7 is hydrogen or C1-6 alkyl； R 8 is C 1-6 alkyl, C 1-6 alkylcarbonyl or di (C 1-6 alkyl) aminoC 1-6 alkyl； and R9 is di (C1-6 alkyl) amino- C1-6 alkyl； or R3 is a group of the formula - (CH2) t-Z- (b-1), in which t is 0, 1 or 2； Z is a heterocyclic ring system selected from ** Formula ** in which each R10 is independently hydrogen, C1-6 alkyl, aminocarbonyl, hydroxy, ** Formula ** C1-6 alkyl C1-6 oxyalkyl, C1 alkyl -6-oxy-C1-6-alkyl, di (C2-6 phenyl-alkenyl), piperidinyl-C1-6 alkyl, C3-10 cycloalkyl, C3-10 cycloalkyl-C1-6 alkyl, aryloxy ( hydroxy) C 1-6 alkyl, haloindazolyl, C 1-6 aryl alkyl, C 2-6 aryl alkenyl, morpholino, C 1-6 alkyl imidazolyl, or pyridinyl C 1-6 alkyl； each R11 is independently hydrogen, hydroxy, piperidinyl or aryl； aryl is phenyl or phenyl substituted with halo, C1-6 alkyl or C1-6 alkyl.Un compuesto de fórmula (I),**Fórmula** una
