This invention provides a glucocorticoid receptor agonist consisting of derivatives of 2,2,4-trimethyl-6-phenyl-1,2-dihydroquinoline with substituted oxy group, and new pharmacological activities for the said agonist.The glucocorticoid receptor agonist consists of compounds of formula (1) or salt thereof, wherein R1is formulae (2a), (3a), (4a) or (5a) R2is -(CO)-R8、 -(CO)O-R9and the like R2-O- is a substitution at position 4 or 5 of beneze ring A R3is low alkyl R4, R5, R6and R7are individually halogen, optionally substituted low alkyl and the like m, n, p and q are individually 0 or 1 R8and R9are individually optionally substituted low alkyl or low alkenyl and the like.發現由具有取代氧基之2,2,4-三甲基-6-苯基-1,2-二氫喹啉衍生物所構成之糖皮質激素受體激動劑及該激動劑之新藥理作用。式(1)表示之化合物或其鹽所構成之糖皮質激素受體激動劑。R1表示式(2a)、(3a)、(4a)或(5a);R2表示-(CO)-R8、-(CO)O-R9等;R2-O-表示取代於苯環A的4或5位置;R3表示低級烷基;R4、R5、R6或R7表示鹵素原子、可有取代基之低級烷基等;m、n、p或q表示0、1等;R8、R9表示可有取代基之低級烷基、低級烯基等
