您的位置: 首页 > 农业专利 > 详情页

Benzotienilo-pirrolotriazinas disustituidas y su uso como inhibidores de la FGFR cinasa
专利权人:
Bayer Pharma Aktiengesellschaft;Bayer Intellectual Property GmbH
发明人:
BROHM, Dirk,HEROULT, Melanie,COLLIN, Marie-Pierre,HÜBSCH, Walter,LOBELL, Mario,LUSTIG, Klemens,GRÜNEWALD, Sylvia,BÖMER, Ulf,VÖHRINGER, Verena
申请号:
ES12798738
公开号:
ES2591203T3
申请日:
2012.12.10
申请国别(地区):
ES
年份:
2016
代理人:
摘要:
A compound of formula (I) ** Formula ** in which R1 is hydrogen, chlorine, methyl or methoxy, R2 is hydrogen or methoxy, provided that at least one of R1 and R2 is different from hydrogen, G1 represents chlorine , (C1-C4) alkyl, (C1-C4) alkoxycarbonyl, member aza-heteroaryl or the group -CH2- OR3, -CH2-NR4R5 or -C (>; = O) -NR4R6, where R3 is hydrogen, alkyl (C1-C4) or cycloalkyl (C3-C6) or phenyl, (i) said (C1-C4) alkyl is optionally substituted with hydroxy, (C1-C4) alkoxy, hydroxycarbonyl, (C1-C4) alkoxycarbonyl, amino, aminocarbonyl , mono- (C1-C4) -alkyl-aminocarbonyl, di-alkylaminocarbonyl (C1-C4) -, cycloalkyl (C3-C6) or up to three fluorine atom, and (ii) said cycloalkyl (C3-C6) is optionally substituted with one or two substituents independently selected from the group consisting of (C1-C4) alkyl, hydroxy and amino, and (iii) said phenyl is optionally substituted with one or two substituents independently selected from the group which with it consists of fluorine, chlorine, bromine, cyano, trifluoromethyl, trifluoromethoxy, (C1-C4) alkyl and (C1-C4) alkoxy, R4 is hydrogen or (C1-C4) alkyl, R5 is hydrogen, (C1-C4) alkyl, (C1-C4) alkylcarbonyl, (C3-C6) cycloalkyl or 4-6 membered heterocycloalkyl, wherein (i) said (C1-C4) alkyl is optionally substituted with hydroxy, (C1-C4) alkoxy, hydroxycarbonyl, alkoxycarbonyl ( C1-C4), aminocarbonyl, mono- (C1-C4) -alkyl-aminocarbonyl, di-alkylaminocarbonyl (C1-C4) or cycloalkyl (C3-C6), and (ii) said cycloalkyl (C3-C6) is optionally substituted with one or two substituents independently selected from the group consisting of (C1-C4) alkyl, hydroxy and amino, and (iii) said 4- to 6-membered heterocycloalkyl is optionally substituted with one or two substituents independently selected from the group consisting of alkyl ( C1-C4), hydroxy, oxo and amino, R6 is hydrogen, (C1-C4) alkyl, (C3-C6) cycloalkyl or 4-6 membered heterocycloalkyl, and where (i) said (C1-C4) alkyl is optionally substituted with hydroxy, (C1-C4) alkoxy,
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充