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MEK N- (arylamino) sulfonamide inhibitors
专利权人:
ARDEA BIOSCIENCES; INC.
发明人:
MADERNA, ANDREAS,VERNIER, JEAN-MICHEL,BARAWKAR, DINESH A.,CHAMAKURA, VARAPRASAD,ABDELLAOUI, HASSAN EL,HONG, ZHI
申请号:
ES06788078
公开号:
ES2481402T3
申请日:
2006.07.21
申请国别(地区):
ES
年份:
2014
代理人:
摘要:
A compound of the formula I: ** Formula ** where G is R1a, R1b, R1c, R1d or R1e; R ° is H, halogen, CH3NH-, (CH3) 2N-, C1-C6 alkyl, C1-C4 alkoxy, C3-C6 cycloalkyl, C2-C6 alkenyl, C2-C6 alkynyl groups, said alkyl, alkoxy, cycloalkyl, alkenyl groups and alkynyl optionally substituted with 1-3 substituents independently selected from: halogen, OH, CN, cyanomethyl, nitro, phenyl and trifluoromethyl and said C1-C6 alkyl and C1-C4 alkoxy groups also optionally substituted with OCH3 or OCH2CH3; X is F, Cl or methyl; Y is I, Br, Cl, CF3, C1-C3 alkyl, C2-C3 alkenyl, C2-C3 alkynyl, cyclopropyl, phenyl, pyridyl, pyrazolyl, OMe, OEt or SMe, where all those methyl, ethyl, C1- alkyl groups C3 and cyclopropyl of X and Y are optionally substituted with OH, where all those phenyl, pyridyl, pyrazolyl groups of Y are optionally substituted with: halogen, acetyl, methyl and trifluoromethyl and where all those methyl groups of X and Y are optionally substituted with one, two or three atoms of F and Z is H or F; wherein R1a is methyl, optionally substituted with 1-3 fluorine atoms or 1-3 chlorine atoms or with OH, cyclopropoxy or C1-C4 alkoxy, wherein said cyclopropoxy group or C1-C4 alkyl moieties of said C1-C4 alkoxy groups they are optionally substituted with a hydroxy or methoxy group and where all C2-C4 alkyl groups in said C1-C4 alkoxy are optionally further substituted with a second OH group; R1b is CH (CH3) -C1-3alkyl or C3-C6 cycloalkyl, said methyl, alkyl and cycloalkyl groups optionally substituted with 1-3 substituents independently selected from F, Cl, Br, I, OH, OCH3 and CN; R1c is (CH2) nOmR ', where m is 0 or 1; where, whose m is 1, n is 2 or 3 and whose m is 0, n is 1 or 2 and where R 'is C1-C6 alkyl, optionally substituted with 1-3 substituents independently selected from F, Cl, OH, OCH3 , OCH2CH3 and C3-C6 cycloalkyl; R1d is C (A) (A ') (B) - where B, A and A' are independently H or C1-4 alkyl, optionally substituted with one or two OH groups or halogen atoms or A and
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