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MEK inhibitors
专利权人:
ARDEA BIOSCIENCES; INC.
发明人:
VERNIER, JEAN-MICHEL,MADERNA, ANDREAS,KOH, YUNG-HYO,HONG, ZHI
申请号:
ES08727965
公开号:
ES2547303T3
申请日:
2008.01.18
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
A compound of formula (I): ** Formula ** in which G is R1a, R1b, R1c, R1d, R1e, Ar1, Ar2 or Ar3; R0, R1 and R2 are independently selected from H, halogen, cyano, cyanomethyl, nitro, difluoromethoxy, difluoromethoxy, trifluoromethyl, azido, C1-C6 alkyl, C1-C4 alkoxy, C3-C6 cycloalkyl, C2-C6 alkenyl, C2 alkynyl C6; wherein said C1-C6 alkyl, C3-C6 cycloalkyl, C2-C6 alkenyl and C2-C6 alkynyl groups are optionally substituted with 1-3 substituents independently selected from halogen, OH, CN, cyanomethyl, nitro, phenyl, difluoromethoxy, difluoromethoxy and trifluoromethyl; said C1-C6 alkyl and C1-C4 alkoxy groups are optionally substituted with OCH3 or OCH2CH3; X is F, Cl or methyl; Y is I, Br, Cl, CF3, C1-C3 alkyl, C2-C3 alkenyl, C2-C3 alkynyl, cyclopropyl, phenyl, pyridyl, pyrazolyl, OMe, OEt, or SMe, wherein all these methyl, ethyl groups, C1-C3 alkyl and cyclopropyl of X and Y are optionally substituted with OH; all these phenyl, pyridyl, pyrazolyl groups of Y are optionally substituted with halogen, acetyl, methyl and trifluoromethyl; and all these methyl groups of X and Y are optionally substituted with one, two or three F atoms; Z is H, methyl, Cl or F; and wherein R1a is methyl, cyclopropoxy or C1-C4 alkoxy; wherein the methyl is optionally substituted with OH, 1-3 fluorine atoms or 1-3 chlorine atoms; C1-C4 alkyl moieties of said C1-C4 alkoxy are optionally substituted with a hydroxy or methoxy group; and all C2-C4 alkyl groups within said C1-C4 alkoxy are optionally further substituted with a second OH group; R1b is CH (CH3) -C1-3 alkyl or C3-C6 cycloalkyl, said CH3, alkyl, and cycloalkyl groups optionally substituted with 1-3 substituents independently selected from F, Cl, Br, I, OH, C1-C4 alkoxy and CN R1c is (CH2) nOmR ', where m is 0 or 1; in which when m is 1, n is 2 or 3, and when m is 0, n is 1 or 2; R 'is C1-C6 alkyl, optionally substituted with 1-3 substituents independently selected from F, Cl, OH, OCH3, OCH2CH3 and C3-C6 cycloalkyl; R1d is C (A ') (A
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