ABBOTT LABORATORIES;ABBVIE INC.;ABBOTT GMBH & CO. KG
发明人:
申请号：
IL21564211
公开号：
IL215642A
申请日:
2011.10.09
申请国别(地区):
IL
年份:
2015
代理人:
摘要：
The present invention relates to N-phenyl-(piperazinyl or homopiperazinyl)-benzenesulfonamide or benzenesulfonyl-phenyl-(piperazine or homopiperazine) compounds, pharmaceutical compositions containing them, and their use in therapy. The compounds possess valuable therapeutic properties and are particularly suitable for treating diseases that respond to modulation of the serotonin 5-HT6 receptor. wherein X is a bond or a group N&mdash；R4； R1 is hydrogen or methyl； R2 is hydrogen or methyl； R3 is hydrogen, C1-C3 alkyl, fluorine, C1-C2 alkoxy or fluorinated C1-C2 alkoxy； R4 is hydrogen, C1-C4 alkyl, C3-C4 cycloalkyl, or C3-C4 cycloalkyl-CH2&mdash；； R5 is hydrogen, fluorine, chlorine, C1-C2 alkyl, fluorinated C1-C2 alkyl, C1-C2 alkoxy or fluorinated C1-C2 alkoxy； R6 is hydrogen, fluorine or chlorine； and n is 1 or 2.
