ADAMS, Christopher,CAPPARELLI, Michael Paul,EHARA, Takeru,KARKI, Rajeshri Ganesh,MAINOLFI, Nello,ZHANG, Chun
申请号：
ES14744744
公开号：
ES2655855T3
申请日:
2014.07.14
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound, or a salt or tautomer thereof, according to formula (I): ** Formula ** (I) wherein: n is 0, 1 or 2； R is hydrogen, alkyl of 1 to 4 carbon atoms, or hydroxy-alkyl of 1 to 4 carbon atoms； R1 is halogen, hydroxyl, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, halo-alkyl of 1 to 6 atoms carbon, hydroxy-alkyl of 1 to 6 carbon atoms, amino-alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms-alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 atoms of carbon-alkoxy of 1 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms-alkoxy of 1 to 6 carbon atoms, halo-alkoxy of 1 to 6 carbon atoms, -S (O) box of 1 to 6 carbon atoms, -CH2NHC (O) -alkyl of 1 to 4 carbon atoms or -OCH2C (O) R7, p is 0, 1 or 2； R2 is alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, hydroxy-alkyl of 1 to 6 carbon atoms or halogen； R3 is hydrogen, halogen, cyano, alkyl of 1 to 4 carbon atoms, halo-alkyl of 1 to 4 carbon atoms, - CH2C (O) R7, 5 or 6 membered phenyl or heteroaryl having 1, 2 or 3 ring heteroatoms independently selected from N, O or S, wherein the phenyl or heteroaryl is optionally substituted with 0, 1 or 2 alkyl groups of 1 to 4 carbon atoms, and wherein the alkyl and halo-alkyl they are optionally substituted with 0 or 1 hydroxyl； R4 is phenyl, naphthyl or heteroaryl, wherein the heteroaryl is a five or six membered heteroaryl having 1, 2 or 3 ring heteroatoms independently selected from N, O or S, and wherein the phenyl or heteroaryl is optionally substituted by R5 and is further substituted by 0 or 1 substituent selected from halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, hydroxy-alkyl of 1 to 4 carbon atoms, hydroxyl, and cyano-methyl； R5 is -C (O) R8, -CH2C (O) R8, R9, -C (O) NHSO2 alkyl of 1 to 4 carbon atoms, -SO2NHC (O) -alkyl of 1 to 4 carbon atoms, -SO2N ( H) m (alkyl of 1 to 4 carbon atoms) 2-m, -SO2-alkyl of 1 to 4 carbon atoms, cyano, halogen, hydr
