Their uses as Medicines, in particular as Drugs for the treatment of conditions and diseases that can be treated by the inhibition of PDE4 Enzyme.Claim 1: pyrimidine compounds of General formula (1) wherein G is an optionally substituted phenyl Substituent with at least a Z or an Aromatic heterocycle of 5 or 6 members optionally substituted with at least one Substituent in the phenyl or Z, where heterocicl Or it can be Condensed with an Aromatic Ring of 4, 5, 6 or 7 members,In The Ring where condensate can be saturated, unsaturated or partially aromatic and can be substituted with at least one Substituent Z； Z regardless of each other is c u2081 u208b u2086 hidroxialquilo c u2081 u208b u2086 alkyl, alkoxy, c u2081 u208b u2086, haloalquilo c u2081 u208b u2086, haloalcoxi c u2081 u208b - sc u2081 u208b u2086 u2086, alkyl, halogen or alkyl, cyano or hydroxyl is so u2082c u2081 u208b u2086, conh u2082, nhso u2082c u2081 u208b u2086 alkyl, alkyl nhcoc u2081 u208b u2086,Where the above-mentioned are branched chain Alkyl or only and can be replaced； t is cr u00b9r u00b2 or s (or S) or u02e3 (OR = NH)； X is 0, 1 or 2； and r u00b9 R u00b2 independently of one another c u2081 u208b u2086 denote Hydrogen, alkyl, alkoxy c u2081 u208b u2086, haloalquilo c u2081 u208b u2086, halogen, or hydroxyl cyan Or,Where the above-mentioned are branched chain Alkyl or only and can be replaced； n is 1 or 2； K is c u2081 u208b u2086 c u2081 u208b u2086 alkyl, alkoxy, halogen, haloalquilo c u2081 u208b u2086, hydroxyl or cyano, where these are branched chain Alkyl or only and can be. Tuidos； and M is 0, 1, 2, 3 or 4； X independently of each other is a c u2081 u208b u2086 c u2083 u208b u2086 alkoxy alkyl, cycloalkyl, c u2081 u208b u2086,Cicloalcoxi c u2083 u208b u2086, haloalquilo c u2081 u208b u2086, haloalcoxi c u2081 u208b u2086, halogen, cyano, carboxyl, hydroxyl, C (o) - nh u2082, alkyl C (o) - NH - c u2081 u208b u2086, c u208do u208e u208bn u208d u2090 u2097q u1d58 u2071 u2097 u2092 c u2
